Exploring the role of graphene-metal hybrid nanomaterials as Raman signal enhancers in early stage cancer detection.

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL Talanta Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI:10.1016/j.talanta.2024.127185

Vrushti Kansara, Mitali Patel

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Abstract

Molecular diagnosis plays a significant role in detection of biomolecules linked to early stage cancer since it offers greater sensitivity and reliability for identification of biomarker level changes as the disease progresses. The application of vibrational spectroscopy in biomarker detection is defined by the fingerprint spectrum of a molecule originating from single-molecule vibrations. This characteristic makes surface enhanced Raman spectroscopy (SERS) a promising tool for identification of biomarkers. The performance of the SERS technique largely depends on the material being used as the SERS substrate. Graphene, with its large surface area and abundance of aromatic regions, is considered advantageous as SERS substrate. Combining graphene with metal nanomaterials considerably increases SERS signal intensity, thereby enhancing detection sensitivity. Therefore, this review emphasizes the significance of selecting graphene-metal nanohybrids as suitable SERS substrates for signal amplification. The detail understanding of the mechanism of graphene-metal hybrid in SERS based detection of early stage cancer is also presented. Furthermore, several examples demonstrated the application of graphene-metal hybrid nanomaterials in detecting biomarkers and cancer cell differentiation using SERS imaging.

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探索石墨烯-金属杂化纳米材料作为拉曼信号增强器在早期癌症检测中的作用。

分子诊断在检测与早期癌症有关的生物分子方面发挥着重要作用，因为随着病情的发展，分子诊断能提供更高的灵敏度和可靠性来识别生物标志物水平的变化。振动光谱法在生物标记物检测中的应用是由单分子振动产生的分子指纹谱决定的。这一特性使得表面增强拉曼光谱（SERS）成为一种很有前途的生物标记物鉴定工具。SERS 技术的性能在很大程度上取决于用作 SERS 基底的材料。石墨烯具有较大的表面积和丰富的芳香区域，被认为是 SERS 基底的有利材料。将石墨烯与金属纳米材料结合可大大增加 SERS 信号强度，从而提高检测灵敏度。因此，本综述强调了选择石墨烯-金属纳米杂化物作为合适的 SERS 基底来放大信号的意义。文中还详细介绍了石墨烯-金属杂化物在基于 SERS 的早期癌症检测中的作用机制。此外，几个实例还展示了石墨烯-金属杂化纳米材料在利用 SERS 成像检测生物标记物和癌细胞分化方面的应用。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.