Risk factors of seizure and complex seizure in febrile children: a clinical study.

IF 2 3区医学 Q2 PEDIATRICS BMC Pediatrics Pub Date : 2024-11-12 DOI:10.1186/s12887-024-05215-x

Farhad Heydarian, Elham Bakhtiari, Mina Bay

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引用次数: 0

Abstract

Purpose: There is some evidence that trace element and mineral deficiencies may promote the occurrence of febrile seizures. However, the role of these elements in the occurrence of complex seizures in children with FS has not been comprehensively investigated. The present study was conducted to evaluate this issue.

Methods: In a cross-sectional study, 220 patients including 110 febrile and 110 FS children aged 6-60 months were studied. Blood samples were taken and serum zinc, potassium, sodium, magnesium and calcium levels were measured. Demographic and clinical characteristics were also recorded.

Results: The patients were similar in age and sex. Higher serum zinc levels decreased the risk of seizure (RR = 0.95, p-value = 0.0001) and complex seizure (OR = 0.96, p-value = 0.03). Higher serum sodium levels decreased the risk of complex seizures (OR = 0.85, p-value = 0.023). Higher serum potassium levels were associated with a lower risk of seizure (OR = 0.55, p-value = 0.035). Serum calcium and magnesium levels were not associated with the risk of seizure and complex seizure. A BMI at the upper end of the normal range decreased the risk of complex seizures (OR = 0.83, p-value = 0.05). Male sex increased the risk of complex seizure (OR = 4.14, p-value = 0.016).

Conclusions: Low serum levels of zinc, potassium and sodium are risk factors for seizure and complex seizure in febrile children. Male sex is also a risk factor for complex seizures. The time from fever to seizure was shorter in younger children. Children with a BMI at the upper end of the normal range have a lower risk of having a complex seizure.

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发热儿童癫痫发作和复合性癫痫发作的风险因素：一项临床研究。

目的：有证据表明，微量元素和矿物质缺乏可能会导致发热性癫痫发作。然而，这些元素在FS患儿复杂性癫痫发作中的作用尚未得到全面研究。本研究旨在评估这一问题：在一项横断面研究中，220 名患者（包括 110 名发热儿童和 110 名 FS 儿童，年龄在 6-60 个月之间）接受了研究。采集血样并测量血清锌、钾、钠、镁和钙水平。研究还记录了人口统计学和临床特征：结果：患者的年龄和性别相似。血清锌水平越高，癫痫发作（RR = 0.95，P 值 = 0.0001）和复杂性癫痫发作（OR = 0.96，P 值 = 0.03）的风险越低。血清钠水平越高，复杂性癫痫发作的风险越低（OR = 0.85，p 值 = 0.023）。血清钾水平越高，癫痫发作的风险越低（OR = 0.55，p 值 = 0.035）。血清钙和镁水平与癫痫发作和复杂性癫痫发作的风险无关。体重指数处于正常范围的上限会降低复杂性癫痫发作的风险（OR = 0.83，P 值 = 0.05）。男性会增加复杂性癫痫发作的风险（OR = 4.14，p 值 = 0.016）：结论：血清锌、钾和钠水平低是发热儿童癫痫发作和复杂性癫痫发作的危险因素。男性也是复杂性癫痫发作的危险因素。年龄较小的儿童从发烧到癫痫发作的时间较短。体重指数处于正常范围上限的儿童出现复杂性癫痫发作的风险较低。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.