Thermosensitive Hydrogels for Periodontal Regeneration: A Systematic Review of the Evidence

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-11-13 DOI:10.1002/cre2.70029

Mohammad Amin Amiri, Delara Amiri, Shahram Hamedani

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Abstract

Objectives

Thermosensitive hydrogels are now among the most commonly used biomaterials in tissue engineering. Due to their unique characteristics, this review aimed to evaluate the suitability of thermosensitive hydrogels in periodontal regeneration.

Material and Methods

PubMed, Scopus, and Web of Science databases were searched until March 25, 2024, to retrieve relevant articles. The eligibility criteria for the included studies were determined by the designed PICO elements. Results from each included study were extracted, focusing on the three main areas: thermosensitivity, cellular characteristics, and in vivo characteristics.

Results

Nineteen studies were included in our study. The thermosensitivity assessment of the hydrogels indicated a range of sol–gel transition times from 40 s to 20 min based on the type of polymers and the fabrication process. The cellular characterization was assessed based on three main cellular behaviors: cellular viability/proliferation, differentiation, and migration. The in vivo characterization was performed based on two main approaches: radiographic and histologic evaluation.

Conclusions

The results indicated that the addition of bioactive agents could enhance the in vivo efficacy of thermosensitive hydrogels in periodontal regeneration through three main areas: antimicrobial, anti-inflammatory, and regenerative effects.

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用于牙周再生的热敏水凝胶：证据的系统回顾。

目的：热敏性水凝胶是目前组织工程中最常用的生物材料之一。由于热敏水凝胶的独特性，本综述旨在评估热敏水凝胶在牙周再生中的适用性：在 2024 年 3 月 25 日前，对 PubMed、Scopus 和 Web of Science 数据库进行了检索，以获取相关文章。根据设计的 PICO 要素确定了纳入研究的资格标准。提取了每项纳入研究的结果，重点关注三个主要方面：热敏感性、细胞特性和体内特性：我们的研究共纳入了 19 项研究。水凝胶的热敏性评估表明，根据聚合物的类型和制造工艺，溶胶-凝胶转变时间的范围从 40 秒到 20 分钟不等。细胞特性评估基于三种主要的细胞行为：细胞活力/增殖、分化和迁移。体内表征主要通过两种方法进行：放射学和组织学评估：研究结果表明，添加生物活性剂可通过抗菌、消炎和再生作用三大方面提高热敏水凝胶在牙周再生中的体内功效。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.