Alkaline phosphatase is useful for predicting giant cell arthritis complications in patients with polymyalgia rheumatica.

IF 1.8 4区医学 Q3 RHEUMATOLOGY Modern Rheumatology Pub Date : 2024-11-14 DOI:10.1093/mr/roae101

Ryo Yamashita, Yusuke Izumi, Jun Hiramoto

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Abstract

Objectives: This study determined whether alkaline phosphatase can be used to distinguish giant cell arthritis complications in patients with polymyalgia rheumatica.

Methods: This retrospective study included patients diagnosed with polymyalgia rheumatica between January 2014 and October 2023 at our hospital. The predictive accuracy of biomarkers for diagnosing giant cell arthritis was evaluated. Logistic regression was performed to identify factors predicting giant cell arthritis complications.

Results: In total, 128 participants were included in this study and divided into two groups: isolated polymyalgia rheumatica (n = 111) and polymyalgia rheumatica with giant cell arthritis (n = 17). The median alkaline phosphatase level of polymyalgia rheumatica with giant cell arthritis group was significantly higher than that of the isolated polymyalgia rheumatica group (242.0 [interquartile range, 221.0-595.0] vs. 187.0 [interquartile range 97.5-254.5] U/L, P < 0.001). Setting a cut-off value of 214 U/L for alkaline phosphatase yielded a sensitivity and specificity of 0.88 and 0.55, respectively, for diagnosing giant cell arteritis. Multivariate analysis revealed that alkaline phosphatase was a significant independent variable in the complications of giant cell arteritis (odds ratio, 25.2; P = 0.032).

Conclusions: Alkaline phosphatase can help distinguish giant cell arthritis complications in patients with polymyalgia rheumatica.

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碱性磷酸酶有助于预测多发性风湿性关节炎患者的巨细胞关节炎并发症。

研究目的本研究确定碱性磷酸酶是否可用于区分多发性风湿痛患者的巨细胞关节炎并发症：这项回顾性研究纳入了2014年1月至2023年10月期间在我院确诊的多发性风湿痛患者。评估了生物标志物对诊断巨细胞性关节炎的预测准确性。通过逻辑回归确定巨细胞关节炎并发症的预测因素：本研究共纳入128名参与者，分为两组：孤立性多肌痛风湿病（111人）和多肌痛风湿病合并巨细胞关节炎（17人）。多发性风湿病伴巨细胞关节炎组的碱性磷酸酶中位数明显高于孤立性多发性风湿病组（242.0 [四分位间范围，221.0-595.0] vs. 187.0 [四分位间范围，97.5-254.5] U/L，P < 0.001）。将碱性磷酸酶的临界值设定为 214 U/L，诊断巨细胞动脉炎的敏感性和特异性分别为 0.88 和 0.55。多变量分析显示，碱性磷酸酶是巨细胞动脉炎并发症的一个重要独立变量（几率比，25.2；P = 0.032）：碱性磷酸酶有助于区分多发性风湿性关节炎患者的巨细胞动脉炎并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Modern Rheumatology RHEUMATOLOGY-

CiteScore

4.90

自引率

9.10%

发文量

146

审稿时长

1.5 months

期刊介绍： Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions