STRIPAK, a fundamental signaling hub of eukaryotic development.

IF 8 1区生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2024-11-11 DOI:10.1128/mmbr.00205-23

Ulrich Kück, Stefanie Pöggeler

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Abstract

SUMMARYThe striatin-interacting phosphatase and kinase (STRIPAK) complex is involved in the regulation of many developmental processes in eukaryotic microorganisms and all animals, including humans. STRIPAK is a component of protein phosphatase 2A (PP2A), a highly conserved serine-threonine phosphatase composed of catalytic subunits (PP2Ac), a scaffolding subunit (PP2AA) and various substrate-directing B regulatory subunits. In particular, the B''' regulatory subunit called striatin has evoked major interest over the last 20 years. Studies in fungal systems have contributed substantially to our current knowledge about STRIPAK composition, assembly, and cellular localization, as well as its regulatory role in autophagy and the morphology of fungal development. STRIPAK represents a signaling hub with many kinases and thus integrates upstream and downstream information from many conserved eukaryotic signaling pathways. A profound understanding of STRIPAK's regulatory role in fungi opens the gateway to understanding the multifarious functions carried out by STRIPAK in higher eukaryotes, including its contribution to malignant cell growth.

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STRIPAK，真核生物发育的基本信号枢纽。

摘要纹蛋白互作磷酸酶和激酶（STRIPAK）复合物参与真核微生物和包括人类在内的所有动物的许多发育过程的调控。STRIPAK 是蛋白磷酸酶 2A（PP2A）的一个组成部分，PP2A 是一种高度保守的丝氨酸-苏氨酸磷酸酶，由催化亚基（PP2Ac）、支架亚基（PP2AA）和各种底物导向 B 调节亚基组成。其中，被称为纹蛋白的 B'''调控亚基在过去 20 年中引起了人们的极大兴趣。对真菌系统的研究极大地促进了我们对 STRIPAK 的组成、组装、细胞定位及其在自噬和真菌发育形态中的调控作用的了解。STRIPAK 是一个信号枢纽，有许多激酶，因此整合了来自许多保守的真核生物信号通路的上游和下游信息。深入了解 STRIPAK 在真菌中的调控作用，为了解 STRIPAK 在高等真核生物中的多种功能（包括其对恶性细胞生长的贡献）打开了大门。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.