Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma.

IF 0.9 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI:10.5455/OVJ.2024.v14.i10.20

Michihito Tagawa, Takamasa Itoi, Ryohei Yoshitake, Kenji Kutara, Natsuki Akashi, Ikki Mitsui, Yasuhiko Okamura

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Abstract

Background: Intracranial histiocytic sarcoma (HS) is uncommon in dogs, and no standard treatment has yet been defined for this disease. Herein, we describe a case of intracranial HS that responded favorably to nimustine treatment.

Case description: A 9-year-old, castrated Welsh Corgi Pembroke presented with a 2-month history of quadriplegia. Intracranial disease was suspected on neurological examination, and magnetic resonance imaging (MRI) revealed a contrast-enhanced mass in the left frontal lobe. Following tissue biopsy, the patient received intravenous nimustine (ACNU) treatment. The patient's neurological symptoms partially improved, and a reduction in tumor volume was observed on MRI on day 99. After three administrations of ACNU, tumor regrowth was confirmed on day 124, and temozolomide was subsequently administered. The patient subsequently showed no major changes in clinical symptoms, but subsequently died suddenly on day 195.

Conclusion: In this case, administration of ACNU provided temporary symptom improvement and tumor reduction. Therefore, ACNU monotherapy may be a therapeutic option for canine intracranial HS.

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尼莫司汀对一只患有颅内组织细胞肉瘤的狗的治疗效果。

背景：颅内组织细胞肉瘤（HS）在犬中并不常见，目前还没有针对这种疾病的标准治疗方法。在此，我们描述了一例对尼莫司汀治疗反应良好的颅内组织细胞肉瘤病例：一只 9 岁的阉割威尔士柯基彭布罗克犬在 2 个月前出现四肢瘫痪。神经系统检查怀疑患者患有颅内疾病，磁共振成像（MRI）显示患者左侧额叶有一个对比度增强的肿块。组织活检后，患者接受了静脉注射尼莫司汀（ACNU）治疗。患者的神经症状得到部分改善，第 99 天的核磁共振成像显示肿瘤体积缩小。经过三次 ACNU 治疗后，第 124 天证实肿瘤重新生长，随后患者接受了替莫唑胺治疗。患者随后的临床症状没有出现重大变化，但在第 195 天突然死亡：在该病例中，使用 ACNU 可暂时改善症状并缩小肿瘤。因此，ACNU单药治疗可能是犬颅内HS的一种治疗选择。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.