Molecularly Imprinted Ratiometric Fluorescent Sensors for Analysis of Pharmaceuticals and Biomarkers.

IF 3.4 3区综合性期刊 Q2 CHEMISTRY, ANALYTICAL Sensors Pub Date : 2024-11-02 DOI:10.3390/s24217068

Jingyi Yan, Siwu Liu, Dani Sun, Siyuan Peng, Yongfei Ming, Abbas Ostovan, Zhihua Song, Jinmao You, Jinhua Li, Huaying Fan

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Abstract

Currently, analyzing pharmaceuticals and biomarkers is crucial for ensuring medication safety and protecting life and health, and there is an urgent need to develop new and efficient analytical techniques in view of the limitations of traditional analytical methods. Molecularly imprinted ratiometric fluorescent (MI-RFL) sensors have received increasing attention in the field of analytical detection due to their high selectivity, sensitivity and anti-interference ability, short response time, and visualization. This review summarizes the recent advances of MI-RFL sensors in the field of pharmaceuticals and biomarkers detection. Firstly, the fluorescence sources and working mechanisms of MI-RFL sensors are briefly introduced. On this basis, new techniques and strategies for preparing molecularly imprinted polymers, such as dummy template imprinting, nanoimprinting, multi-template imprinting, and stimulus-responsive imprinting strategies, are presented. Then, dual- and triple-emission types of fluorescent sensors are introduced. Subsequently, specific applications of MI-RFL sensors in pharmaceutical analysis and biomarkers detection are highlighted. In addition, innovative applications of MI-RFL sensors in point-of-care testing are discussed in-depth. Finally, the challenges of MI-RFL sensors for analysis of pharmaceuticals and biomarkers are proposed, and the research outlook and development trends of MI-RFL sensors are prospected.

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用于分析药物和生物标记物的分子印迹比率荧光传感器。

目前，分析药物和生物标记物对于确保用药安全、保护生命健康至关重要，鉴于传统分析方法的局限性，迫切需要开发新的高效分析技术。分子印迹比率荧光（MI-RFL）传感器具有选择性高、灵敏度高、抗干扰能力强、响应时间短、可视化等优点，在分析检测领域受到越来越多的关注。本综述总结了 MI-RFL 传感器在药物和生物标记物检测领域的最新进展。首先，简要介绍了 MI-RFL 传感器的荧光源和工作机制。在此基础上，介绍了制备分子印迹聚合物的新技术和新策略，如假模板印迹、纳米印迹、多模板印迹和刺激响应印迹策略。然后，介绍了双发射和三发射类型的荧光传感器。随后，重点介绍了 MI-RFL 传感器在药物分析和生物标记检测中的具体应用。此外，还深入讨论了 MI-RFL 传感器在护理点检测中的创新应用。最后，提出了 MI-RFL 传感器在药物和生物标记物分析中面临的挑战，并展望了 MI-RFL 传感器的研究前景和发展趋势。

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来源期刊

Sensors 工程技术-电化学

CiteScore

7.30

自引率

12.80%

发文量

8430

审稿时长

1.7 months

期刊介绍： Sensors (ISSN 1424-8220) provides an advanced forum for the science and technology of sensors and biosensors. It publishes reviews (including comprehensive reviews on the complete sensors products), regular research papers and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.