Genomic epidemiology of early SARS-CoV-2 transmission dynamics in Bangladesh.

IF 4 3区医学 Q2 VIROLOGY Virology Journal Pub Date : 2024-11-13 DOI:10.1186/s12985-024-02560-2

L Carnegie, J T McCrone, L du Plessis, M Hasan, M Z Ali, R Begum, M Z Hassan, S Islam, M H Rahman, A S M Uddin, M S Sarker, T Das, M Hossain, M Khan, M H Razu, A Akram, S Arina, E Hoque, M M A Molla, T Nafisaa, P Angra, A Rambaut, S T Pullan, K L Osman, M A Hoque, P Biswas, M S Flora, J Raghwani, G Fournié, M A Samad, S C Hill

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Abstract

Background: Genomic epidemiology has helped reconstruct the global and regional movement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is still a lack of understanding of SARS-CoV-2 spread in some of the world's least developed countries (LDCs).

Methods: To begin to address this disparity, we studied the transmission dynamics of the virus in Bangladesh during the country's first COVID-19 wave by analysing case reports and whole-genome sequences from all eight divisions of the country.

Results: We detected > 50 virus introductions to the country during the period, including during a period of national lockdown. Additionally, through discrete phylogeographic analyses, we identified that geographical distance and population -density and/or -size influenced virus spatial dispersal in Bangladesh.

Conclusions: Overall, this study expands our knowledge of SARS-CoV-2 genomic epidemiology in Bangladesh, shedding light on crucial transmission characteristics within the country, while also acknowledging resemblances and differences to patterns observed in other nations.

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孟加拉国早期 SARS-CoV-2 传播动态的基因组流行病学。

背景：基因组流行病学有助于重建严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）在全球和地区范围内的传播。然而，人们对 SARS-CoV-2 在世界上一些最不发达国家（LDCs）的传播情况仍然缺乏了解：为了着手解决这一差异，我们通过分析病例报告和来自该国所有八个分区的全基因组序列，研究了孟加拉国第一次 COVID-19 浪潮期间的病毒传播动态：结果：在此期间，包括在全国封锁期间，我们检测到有超过 50 种病毒传入该国。此外，通过离散系统地理学分析，我们发现地理距离和人口密度和/或规模影响了病毒在孟加拉国的空间扩散：总之，这项研究扩大了我们对孟加拉国 SARS-CoV-2 基因组流行病学的了解，揭示了该国的关键传播特征，同时也承认了与其他国家观察到的模式的相似之处和不同之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.