Saccharomyces Genome Database: Advances in Genome Annotation, Expanded Biochemical Pathways, and Other Key Enhancements.

IF 3.3 3区生物学 Q2 GENETICS & HEREDITY Genetics Pub Date : 2024-11-12 DOI:10.1093/genetics/iyae185

Stacia R Engel, Suzi Aleksander, Robert S Nash, Edith D Wong, Shuai Weng, Stuart R Miyasato, Gavin Sherlock, J Michael Cherry

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Abstract

Budding yeast (Saccharomyces cerevisiae) is the most extensively characterized eukaryotic model organism and has long been used to gain insight into the fundamentals of genetics, cellular biology, and the functions of specific genes and proteins. The Saccharomyces Genome Database (SGD) is a scientific resource that provides information about the genome and biology of S. cerevisiae. For more than 30 years, SGD has maintained the genetic nomenclature, chromosome maps, and functional annotation for budding yeast along with search and analysis tools to explore these data. Here we describe recent updates at SGD, including the two most recent reference genome annotation updates, expanded biochemical pathways representation, changes to SGD search and data files, and other enhancements to the SGD website and user interface. These activities are part of our continuing effort to promote insights gained from yeast to enable the discovery of functional relationships between sequence and gene products in fungi and higher eukaryotes.

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酵母菌基因组数据库：基因组注释的进展、生化途径的扩展以及其他关键改进。

芽殖酵母（Saccharomyces cerevisiae）是特征最丰富的真核模式生物，长期以来一直被用来深入研究遗传学基础、细胞生物学以及特定基因和蛋白质的功能。酵母菌基因组数据库（SGD）是提供酵母菌基因组和生物学信息的科学资源。30 多年来，SGD 一直在维护芽殖酵母的遗传命名法、染色体图谱和功能注释，以及探索这些数据的搜索和分析工具。在此，我们将介绍 SGD 的最新更新，包括两次最新的参考基因组注释更新、生化途径表述的扩展、SGD 搜索和数据文件的更改以及 SGD 网站和用户界面的其他改进。我们将继续努力推广从酵母中获得的洞察力，以便发现真菌和高等真核生物中序列与基因产物之间的功能关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics GENETICS & HEREDITY-

CiteScore

6.90

自引率

6.10%

发文量

177

审稿时长

1.5 months

期刊介绍： GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.