Management of Dry Mouth Toxicity Following 177Lu-PSMA-617 Radioligand Therapy.

IF 3.4 3区 医学 Q2 ONCOLOGY Practical Radiation Oncology Pub Date : 2024-11-09 DOI:10.1016/j.prro.2024.10.014
Abigail Pepin, Ana Kiess, J Nicholas Lukens, Philipose Mulugeta, Neil K Taunk
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Abstract

Treatment options for patients with metastatic castration-resistant prostate cancer include the use of radioligand therapy with 177Lu-PSMA-617. Although 177Lu-PSMA-617 can selectively target prostate cancer cells, salivary glands express PSMA on the apical lumen of the acinar epithelium. Xerostomia resulting from the use of radioligand therapy is common. Herein, we report on a case of a Common Terminology Criteria for Adverse Events version 5 grade 2 dry mouth event after administration of 177Lu-PSMA-617. The patient was managed with oral hygiene and xerostomia mitigation strategies using oral rinses.

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177Lu-PSMA-617放射性配体治疗后的口干毒性处理。
转移性耐受性前列腺癌患者的治疗方案包括使用 177Lu-PSMA-617 放射配体疗法。虽然 177Lu-PSMA-617 可用于选择性地靶向前列腺癌细胞,但唾液腺在尖状上皮的顶端管腔中表达 PSMA。使用放射性配体治疗导致的口腔干燥症很常见。在此,我们报告了一例在使用 177Lu-PSMA-617 后出现 2 级口干的不良事件通用术语标准版本 5 的病例。患者通过口腔卫生和口腔漱口水缓解口干症状。
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来源期刊
Practical Radiation Oncology
Practical Radiation Oncology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.20
自引率
6.10%
发文量
177
审稿时长
34 days
期刊介绍: The overarching mission of Practical Radiation Oncology is to improve the quality of radiation oncology practice. PRO''s purpose is to document the state of current practice, providing background for those in training and continuing education for practitioners, through discussion and illustration of new techniques, evaluation of current practices, and publication of case reports. PRO strives to provide its readers content that emphasizes knowledge "with a purpose." The content of PRO includes: Original articles focusing on patient safety, quality measurement, or quality improvement initiatives Original articles focusing on imaging, contouring, target delineation, simulation, treatment planning, immobilization, organ motion, and other practical issues ASTRO guidelines, position papers, and consensus statements Essays that highlight enriching personal experiences in caring for cancer patients and their families.
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