The Kaposi sarcoma herpesvirus control of monocytes, macrophages, and the tumour microenvironment

Abstract

Kaposi sarcoma herpesvirus (KSHV) is an oncogenic DNA virus associated with various malignancies, including tumours like Kaposi sarcoma and Primary effusion lymphoma. Recently, the importance of the tumour microenvironment in KSHV-associated tumours is being studied. New studies utilizing human primary cells, co-culture experiments with KSHV-infected cells, and modern techniques like time-resolved single cell analysis, have significantly advanced the understanding of KSHV interactions with monocytes and macrophages. These cells play key roles in shaping the tumour microenvironment. It has become clear that KSHV-infected endothelial cells regulate the growth and the differentiation of monocytes and macrophages. Monocytes and macrophages, in turn, can regulate KSHV-infected cells in tumorigenesis and cytokine secretion, leading to the pro-tumour microenvironment. Further investigations into the viral regulation of monocytes and macrophages thus have potential to lead to the discovery of novel antitumour therapeutics.