Executive functions disorders in children with frontal and temporal epilepsy

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES Epilepsy & Behavior Pub Date : 2024-11-15 DOI:10.1016/j.yebeh.2024.110124

Amanda Guerra , Rafika Fliss , Mélodie Campiglia , Julie Remaud , Olivier Cadeau , Caroline Seegmuller , Clotilde Boulay , Lucas Gauer , Patrick Van Bogaert , Nathalie de Grissac-Moriez , Maria Paola Valenti Hirsch , Mathieu Kuchenbuch , Jean-Luc Roulin , Nathalie Fournet , Didier Le Gall , Arnaud Roy

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Abstract

Introduction

Children with focal epilepsy often present with executive functions (EFs) deficits. EFs deficits can contribute to adaptive challenges and have a negative impact on academic achievement. The purpose of this study was to investigate the EFs profiles of children diagnosed with frontal lobe epilepsy or temporal lobe epilepsy. Also, we aimed to examine the impact of medical and sociodemographic features on executive functioning and to compare the results of performance-based tests and ratings measures.

Method

EFs were assessed using performance based-tests and rating scales. The Child Executive Functions Battery (CEF-B) and the Behavior Rating Inventory of Executive Function (BRIEF) for parents and teachers were used.

Results

Fifty children aged 6–16 years participated in the study, 28 diagnosed with frontal lobe epilepsy and 22 diagnosed with temporal lobe epilepsy. Results showed that approximately 30 % of both groups of epilepsy patients had significant deficits in EFs compared to normative data. Deficits were observed across various domains of EFs (inhibition, working memory, flexibility and planning). Most patients exhibited deficits in one or two of the 4 domains. Worse executive performances were significantly associated with older age at assessment time, longer duration of epilepsy, higher seizure frequency, earlier age at onset and higher number of anti-seizure medication. Additionally, correlation and congruence analyses showed significant discrepancies between the performance-based and rating measures of executive functioning.

Conclusion

Our findings provide substantial evidence of significant executive deficits in children with FLE and TLE and support the clinical validity of the CEF-B battery in this population. The low level of agreement between performance tests and daily life questionnaires suggests that the two methods are complementary for understanding children’s executive functioning. Comprehensive assessment and targeted interventions to address EFs difficulties are recommended for this particular population.

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额叶和颞叶癫痫患儿的执行功能障碍。

简介：患局灶性癫痫的儿童经常出现执行功能（EFs）缺陷。执行功能缺陷可导致适应困难，并对学业成绩产生负面影响。本研究旨在调查被诊断患有额叶癫痫或颞叶癫痫的儿童的执行功能特征。此外，我们还旨在研究医学和社会人口学特征对执行功能的影响，并比较基于表现的测试和评分测量的结果：方法：使用基于表现的测试和评分量表对执行功能进行评估。结果：50 名 6-16 岁的儿童参加了该研究：参加研究的 50 名儿童年龄在 6-16 岁之间，其中 28 名被诊断为额叶癫痫，22 名被诊断为颞叶癫痫。结果显示，与常模数据相比，两组癫痫患者中约有 30% 的儿童在 EF 方面存在明显缺陷。在各领域的 EFs（抑制、工作记忆、灵活性和计划性）中都观察到了缺陷。大多数患者在四个领域中的一个或两个领域表现出缺陷。执行能力较差与评估时年龄较大、癫痫持续时间较长、癫痫发作频率较高、发病年龄较早以及服用抗癫痫药物次数较多有明显关系。此外，相关性和一致性分析表明，以表现为基础的执行功能测量与评级测量之间存在明显差异：我们的研究结果提供了大量证据，证明FLE和TLE患儿存在明显的执行功能缺陷，并支持CEF-B测试在这一人群中的临床有效性。表现测试与日常生活问卷之间的一致性较低，这表明这两种方法在了解儿童的执行功能方面具有互补性。建议对这一特殊人群进行全面评估和有针对性的干预，以解决执行功能方面的困难。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.