O. V. Andreeva, M. G. Belenok, I. Yu. Strobykina, L. F. Saifina, A. P. Lyubina, A. S. Sapunova, A. D. Voloshina, B. F. Garifullin, V. E. Semenov, V. E. Kataev
{"title":"Synthesis and Cytotoxicity Against M-HeLa, HuTu 80, and MCF-7 Human Cancer Cells of the First Nucleoterpenoids of the Isosteviol Diterpenoid Platform","authors":"O. V. Andreeva, M. G. Belenok, I. Yu. Strobykina, L. F. Saifina, A. P. Lyubina, A. S. Sapunova, A. D. Voloshina, B. F. Garifullin, V. E. Semenov, V. E. Kataev","doi":"10.1007/s10600-024-04520-2","DOIUrl":null,"url":null,"abstract":"<p>Conjugates of the diterpenoid isosteviol with uracil and 6-methyluracil (nucleoterpenoids) were synthesized and showed moderate <i>in vitro</i> cytotoxicity (IC<sub>50</sub> values in the range 11.6–51.0 μM) against M-HeLa, HuTu 80, and MCF-7 human cancer cells.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"60 6","pages":"1061 - 1065"},"PeriodicalIF":0.8000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-024-04520-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Conjugates of the diterpenoid isosteviol with uracil and 6-methyluracil (nucleoterpenoids) were synthesized and showed moderate in vitro cytotoxicity (IC50 values in the range 11.6–51.0 μM) against M-HeLa, HuTu 80, and MCF-7 human cancer cells.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
