Human oncogenic viruses: a focus on head and neck carcinogenesis: a systematic review and meta-analysis.

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-10-30 DOI:10.1016/j.oooo.2024.10.082

Antonia Taiane Lopes de Moraes, Erison Santana Dos Santos, Caíque Mariano Pedroso, Rafael Tomaz Gomes, Renata Ferrarotto, Alan Roger Santos-Silva

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Abstract

Objective: This systematic review aimed at identifying oncoviruses associated with head and neck malignant neoplasms (HNC).

Study design: Five databases and grey literature sources were searched following PRISMA guidelines. The risk of bias in individual studies was analyzed using the Joanna Briggs Institute checklist, and the certainty of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation tool.

Results: One hundred and 19 studies were included in the qualitative synthesis. Gathered results of 57 studies were combined in a meta-analysis revealing a significant link between oncoviruses and the development of head and neck cancer, with the most common viruses identified were human papillomavirus (HPV)-16, HPV-18, and Epstein-Barr virus. More studies are needed to clarify the association of human cytomegalovirus and Merkel Cell Polyomavirus with HNC.

Conclusions: Although the role of viruses in cancer onset has been studied for years, our results demonstrated using a meta-analysis that these viruses are associated with HNC.

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人类致癌病毒：关注头颈部癌变：系统回顾和荟萃分析。

目的：本系统综述旨在确定与头颈部恶性肿瘤（HNC）相关的肿瘤病毒：本系统综述旨在确定与头颈部恶性肿瘤（HNC）相关的肿瘤病毒：研究设计：按照 PRISMA 指南检索了五个数据库和灰色文献来源。使用乔安娜-布里格斯研究所（Joanna Briggs Institute）的检查表分析了各项研究的偏倚风险，并使用推荐、评估、发展和评价分级工具对证据的确定性进行了评估：定性综合纳入了 119 项研究。在一项荟萃分析中合并了 57 项研究的结果，结果显示肿瘤病毒与头颈癌的发生有重要联系，其中最常见的病毒是人乳头瘤病毒 (HPV)-16、HPV-18 和 Epstein-Barr 病毒。要明确人类巨细胞病毒和梅克尔细胞多瘤病毒与HNC的关系，还需要更多的研究：尽管病毒在癌症发病中的作用已被研究多年，但我们的研究结果通过荟萃分析表明，这些病毒与HNC有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.

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Table of Contents Editorial Board Society Page Information for Readers Acknowledgement to Reviewers 2024