Cardiac Complications of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T Cell Therapy

IF 1.6 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology Clinics Pub Date : 2025-02-01 Epub Date: 2024-08-30 DOI:10.1016/j.ccl.2024.07.001

Bhargav Makwana MD , Aishwarya Malode MD , Sumanth Khadke MD , Vahin Patel MD , Rushin Shah MD , Manav Patel MD , Aneri Parikh MD , Sourbha S. Dani MD , Sarju Ganatra MD

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免疫检查点抑制剂和嵌合抗原受体 T 细胞疗法的心脏并发症。

免疫检查点抑制剂和嵌合抗原受体T细胞疗法为癌症治疗带来了革命性的变化，但也可能通过免疫相关不良事件导致危及生命的心血管毒性。心肌炎是免疫检查点抑制剂最常见的潜在致命毒性。T细胞疗法有可能导致细胞因子释放综合征。ICI-心肌炎的诊断需要多模式方法，包括生物标记物、成像和心内膜活检，而CRS的特征是类似于分布性休克的临床综合征。处理方法包括停止违规治疗，对 ICI 心肌炎使用皮质类固醇进行免疫抑制，对 CRS 使用白细胞介素-6 拮抗剂。肿瘤专家和心脏病专家之间的合作对于早期识别和及时治疗至关重要。

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来源期刊

Cardiology Clinics 医学-心血管系统

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published four times a year—in February, May, August, and November—Cardiology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Tailored to meet the needs of those in the field of cardiology, each issue focuses on a single cardiology topic, including acute coronary syndromes/cardiac emergencies, coronary artery disease, heart failure, heart rhythm disorders, and much more.

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