Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-Barré Syndrome - Yunnan Province, China, 2018-2023.
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Abstract
What is already known about this topic?: Lipooligosaccharides from Campylobacter jejuni (C. jejuni) have a mimicry antigen structure with gangliosides, which explains the mechanism by which C. jejuni caused Guillain-Barré syndrome (GBS).
What is added by this report?: All 12 C. jejuni strains with class R LOSs and specific serotypes were isolated from seagulls in south China. These emerging C. jejuni strains had ganglioside-mimicry antigen structures and possessed a high potential for triggering GBS.
What are the implications for public health practice?: Sialylated lipooligosaccharides (LOS) class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.
关于这一主题的已知信息空肠弯曲菌（C. jejuni）的脂寡糖与神经节苷脂具有拟态抗原结构，这解释了空肠弯曲菌导致吉兰-巴雷综合征（GBS）的机制：所有 12 株具有 R 类 LOS 和特定血清型的空肠大肠杆菌都是从中国南方的海鸥中分离出来的。这些新出现的空肠大肠杆菌菌株具有神经节苷脂模拟抗原结构，诱发GBS的可能性很高。对公共卫生实践有何意义？ 从海鸥中分离到的R类ialylated lipooligosaccharides（LOS）和GBS相关血清型突显了沿海或湖滨地区诱发GBS的风险。
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