The PCSK9 Protein Is Not Necessarily a Risk Factor for Major Depressive Disorder.

IF 1 Q4 NEUROSCIENCES Basic and Clinical Neuroscience Pub Date : 2024-07-01 DOI:10.32598/bcn.2022.4044.1

Elahe Habibitabar, Shima Khanverdiloo, Mona Doostizadeh, Leila Jahangard, Jamshid Karimi, Gholamreza Shafiee

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Abstract

Introduction: Major depressive disorder (MDD) is one of the common psychiatric disorders that is characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) is important in cholesterol homeostasis.

Methods: This study aimed to investigate PCSK9 levels and oxidative stress with MDD disease. The study included 30 patients with MDD and 30 healthy controls. Their blood samples were collected in sterile tubes, and the serum PCSK9 concentration, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were determined by ELISA kits. Total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and copper concentration were determined manually. There was a significant increase in PCSK9 levels in the patient group (P<0.05).

Results: The receiver operating characteristic (ROC) curve with a sensitivity of 57% and specificity of 52% was 0.928 (95% CI, 0.86-0.996) for PCSK9 in the patient group (P<0.001). It was found that MDA (P=0.036) level was higher in the MDD group, but TAC (P=0.445) level, SOD (P=0.148), GPx (P=0.019) activities, and copper concentration were lower in the patient group compared with the control group.

Conclusion: The study results confirm the relationship between oxidative stress and MDD and also suggest a link between PCSK9 and MDD disease.

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PCSK9蛋白并不一定是重度抑郁症的风险因素。

简介重度抑郁症（MDD）是常见的精神疾病之一，其特征是神经生物学反应异常。Proprotein convertase subtilisin/kexin 9（PCSK9）在胆固醇平衡中起着重要作用：本研究旨在调查PCSK9水平和氧化应激与MDD疾病的关系。研究对象包括 30 名 MDD 患者和 30 名健康对照者。用无菌试管采集他们的血样，用 ELISA 试剂盒测定血清 PCSK9 浓度、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性。总抗氧化能力（TAC）、总氧化状态（TOS）、丙二醛（MDA）和铜浓度由人工测定。患者组的 PCSK9 水平明显升高（PResults：患者组 PCSK9 的接收器操作特征（ROC）曲线为 0.928（95% CI，0.86-0.996），灵敏度为 57%，特异度为 52%：研究结果证实了氧化应激与 MDD 之间的关系，同时也表明 PCSK9 与 MDD 疾病之间存在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.