Oral manifestations as the first sign of Granulomatosis with polyangiitis – A case report

Yousra Akhlef , Ulrik Ørsø Andersen , Preben Homøe
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Abstract

Granulomatosis with polyangiitis (GPA) is a rare and potentially life-threatening systemic vasculitis characterized by necrotizing granulomatous inflammation of small- to medium-sized vessels. This case reports a unique case of a 38-year-old woman who presents with strawberry gingivitis as the first sign of GPA. The patient was seen in different departments and was finally diagnosed with GPA after a delay of 3 months from the first sign of gingival lesions. The patient did not suffer from any serious complications of this delay besides from tinnitus, reduced hearing and sensitivity to sound. The present case highlights the importance of early recognition of the oral manifestations of GPA in order to start the comprehensive treatment timely for successful outcome.
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作为多血管炎肉芽肿病首发症状的口腔表现--病例报告
肉芽肿伴多血管炎(GPA)是一种罕见的、可能危及生命的全身性血管炎,其特征是中小型血管的坏死性肉芽肿炎症。本病例报告了一例独特的病例,患者是一名 38 岁女性,以草莓状牙龈炎作为 GPA 的首发症状。患者曾在不同科室就诊,在出现牙龈病变的第一个征兆后拖延了 3 个月,最终被确诊为 GPA。除了耳鸣、听力下降和对声音敏感之外,患者并没有因延误就诊而出现任何严重的并发症。本病例强调了早期识别 GPA 口腔表现的重要性,以便及时开始综合治疗,获得成功的结果。
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