Front Cover: Photochemical Vs Thermal Acid Catalysed Cyclization of Cannabigerol (CBG): An Unexpected Selectivity (ChemPhotoChem 11/2024)

Abstract

The Front Cover highlights investigations of the reactivity of Cannabigerol (CBG) in organic solvents under both photochemical and acid catalyzed conditions, pointing out the key role of the photoexcited CBG* in the selective formation of a 2,2-disubstituted-chromane derivative (green path). On the other hand, in the presence of Brønsted-Lowry acids, two tertiary carbocations are competitively generated (I⁺, II⁺, orange and blue paths). Finally, when performing the reaction in toluene in the presence of BF₃*OEt₂, a Friedel Crafts-like alkylation of the solvent was noticed (purple paths). More information can be found in the Research Article by Daniele Merli, Stefano Protti, and co-workers (DOI: 10.1002/cptc.202400157).