Dr. Miran Lemmerer, Dr. Veronica Tona, Dr. David Just, Miloš Vavrík, Dr. Boris Maryasin, Dr. Giovanni Di Mauro, Dr. Andreas B. zur Bonsen, Dr. Daniel Kaiser, Prof. Dr. Nuno Maulide
{"title":"Iodide Anion Enables a Reductive Cross-Electrophile Coupling for Preparing Tertiary Amines","authors":"Dr. Miran Lemmerer, Dr. Veronica Tona, Dr. David Just, Miloš Vavrík, Dr. Boris Maryasin, Dr. Giovanni Di Mauro, Dr. Andreas B. zur Bonsen, Dr. Daniel Kaiser, Prof. Dr. Nuno Maulide","doi":"10.1002/anie.202409688","DOIUrl":null,"url":null,"abstract":"<p>The reducing power of iodide anion is an underexplored property that can be used for the cross-electrophile coupling of organic molecules. Herein we harness this trait for the preparation of tertiary amines through the combination of two simple reagents: an electrophilic-carbon precursor and an iminium iodide in a dual role – both as nitrogen-containing building block and as reducing agent. The underlying mechanism of this new C−C bond-formation paradigm is explored through a combination of experiment and quantum chemical calculations.</p>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"64 2","pages":""},"PeriodicalIF":16.9000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720395/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie International Edition","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/anie.202409688","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The reducing power of iodide anion is an underexplored property that can be used for the cross-electrophile coupling of organic molecules. Herein we harness this trait for the preparation of tertiary amines through the combination of two simple reagents: an electrophilic-carbon precursor and an iminium iodide in a dual role – both as nitrogen-containing building block and as reducing agent. The underlying mechanism of this new C−C bond-formation paradigm is explored through a combination of experiment and quantum chemical calculations.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
