Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-11-06 DOI:10.1039/d4ob01581a
Yun Jia , Zhi-Jiang Jiang , Jiawei Han , Kenan Wang , Si-Han Xu , Jian-Fei Bai , Jia Chen , Yifeng Han , Zhanghua Gao
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Abstract

Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.

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机械化学促进银催化杂环戊烯的直接 H/D 交换。
尽管最近在 H/D 交换方面取得了进展,但由于聚烯烃的不溶性和疏水性,对其进行有效脱氘仍然具有挑战性。本研究提出了一种机械化学促进直接 H/D 交换的概念验证。以重水为氘源,银催化的杂多烯烃氘交换在研磨 99 分钟内顺利进行。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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