{"title":"Lipid Particles as Promising Carriers of Radioactive Pharmaceuticles","authors":"A. D. Shirokikh, A. A. Fenin, M. Yu. Koroleva","doi":"10.1134/S0036024424702108","DOIUrl":null,"url":null,"abstract":"<p>Lipid nanoparticles such as nanoemulsions, nanostructured and solid lipid particles made of stearic acid and paraffin oil and stabilized with a mixture of nonionic surfactants Tween 60 and Span 60 are studied. The effect of incorporated yttrium stearate (YSt) as an additive in the modelling of radiopharmaceuticals and radiotherapy on the physicochemical properties of lipid nanoparticles is considered. The resultes indicate that the size of the oil droplets changes slightly when YSt is included in the nanoemulsions. The incorporation of YSt into lipid nanoparticles with stearic acid reduces their size, due apparently to the incorporation of YSt into the adsorption layer together with stearic acid. The studied lipid nanoparticles are resistant to radioactive irradiation with a dose of 5 kGy. No changes in the molecular structure of the components are observed after irradiation, and the aggregative stability of the lipid nanoparticles is not changed.</p>","PeriodicalId":767,"journal":{"name":"Russian Journal of Physical Chemistry A","volume":"98 12","pages":"2842 - 2848"},"PeriodicalIF":0.7000,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry A","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0036024424702108","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Lipid nanoparticles such as nanoemulsions, nanostructured and solid lipid particles made of stearic acid and paraffin oil and stabilized with a mixture of nonionic surfactants Tween 60 and Span 60 are studied. The effect of incorporated yttrium stearate (YSt) as an additive in the modelling of radiopharmaceuticals and radiotherapy on the physicochemical properties of lipid nanoparticles is considered. The resultes indicate that the size of the oil droplets changes slightly when YSt is included in the nanoemulsions. The incorporation of YSt into lipid nanoparticles with stearic acid reduces their size, due apparently to the incorporation of YSt into the adsorption layer together with stearic acid. The studied lipid nanoparticles are resistant to radioactive irradiation with a dose of 5 kGy. No changes in the molecular structure of the components are observed after irradiation, and the aggregative stability of the lipid nanoparticles is not changed.
期刊介绍：
Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world.
Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.
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