Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan, Zhihao Wang
{"title":"Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent.","authors":"Wei Liu, Dan Zhao, Dongxue Yin, Kai Duan, Zhihao Wang","doi":"10.1002/cbdv.202402375","DOIUrl":null,"url":null,"abstract":"<p><p>Pharmacological studies have shown that podophyllotoxin (PTOX) has anti-tumor, antiviral and anti-inflammatory effects. More and more derivatives of PTOX, such as VM-26, NK-611 and GL-331, have gradually been synthesized and widely used in clinical practice. Sinopodophyllum hexandrum rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on S. hexandrum mainly focuses on artificial cultivation, chemical compositions, pharmaceutical value and the biosynthesis pathway of PTOX. However, the researches are relatively scattered and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation in terms of the plant origin source, content profile, and biological activities, in order to provide an integrated reference for in-depth research and clinical application of PTOX in the chemistry and pharmacy fields, which can promote the innovative utilization of S. hexandrum resources and research and development of new anticancer drugs.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202402375"},"PeriodicalIF":2.3000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/cbdv.202402375","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pharmacological studies have shown that podophyllotoxin (PTOX) has anti-tumor, antiviral and anti-inflammatory effects. More and more derivatives of PTOX, such as VM-26, NK-611 and GL-331, have gradually been synthesized and widely used in clinical practice. Sinopodophyllum hexandrum rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on S. hexandrum mainly focuses on artificial cultivation, chemical compositions, pharmaceutical value and the biosynthesis pathway of PTOX. However, the researches are relatively scattered and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation in terms of the plant origin source, content profile, and biological activities, in order to provide an integrated reference for in-depth research and clinical application of PTOX in the chemistry and pharmacy fields, which can promote the innovative utilization of S. hexandrum resources and research and development of new anticancer drugs.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
