{"title":"Acid-Responsive Liposomal Nanodrug with promoted Tumor Penetration for Photoacoustic Imaging-Guided Sonodynamic Therapy","authors":"Xiangli Li, Wen-Jing Tang, Wei Wang, Shuzhen Yue, Huiqin Yao, Jun-Jie Zhu","doi":"10.1039/d4cc05043f","DOIUrl":null,"url":null,"abstract":"Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O<small><sub>2</sub></small>)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O<small><sub>2</sub></small>-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc05043f","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O2)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O2-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.
期刊介绍：
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
