Xiangli Li , Wen-Jing Tang , Wei Wang , Shuzhen Yue , Huiqin Yao , Jun-Jie Zhu
{"title":"Acid-responsive liposomal nanodrug with promoted tumor penetration for photoacoustic imaging-guided sonodynamic therapy†","authors":"Xiangli Li , Wen-Jing Tang , Wei Wang , Shuzhen Yue , Huiqin Yao , Jun-Jie Zhu","doi":"10.1039/d4cc05043f","DOIUrl":null,"url":null,"abstract":"<div><div>Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O<sub>2</sub>)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O<sub>2</sub>-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"60 100","pages":"Pages 15023-15026"},"PeriodicalIF":4.2000,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734524024984","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Herein, an acid-responsive liposomal nanodrug was developed for photoacoustic (PA) imaging-guided oxygen (O2)-independent sonodynamic therapy (SDT). This liposomal nanodrug offers several advantages: (i) it facilitates O2-independent alkyl radical generation upon ultrasound irradiation, (ii) it exhibits acid-responsive charge reversion that enhances tumor penetration, and (iii) it enables activated PA imaging for therapeutic feedback.
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