[68Ga]Ga-PSMA-617 PET/MRI for imaging patients suspected of hepatocellular carcinoma

IF 8.6 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Journal of Nuclear Medicine and Molecular Imaging Pub Date : 2024-11-21 DOI:10.1007/s00259-024-06973-7

Chunxia Qin, Xiangming Song, Shiran Sun, Yangmeihui Song, Weiwei Ruan, Yongkang Gai, Ming Yang, Chidan Wan, Xiaoli Lan

{"title":"[68Ga]Ga-PSMA-617 PET/MRI for imaging patients suspected of hepatocellular carcinoma","authors":"Chunxia Qin, Xiangming Song, Shiran Sun, Yangmeihui Song, Weiwei Ruan, Yongkang Gai, Ming Yang, Chidan Wan, Xiaoli Lan","doi":"10.1007/s00259-024-06973-7","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Radiolabeled probes targeting prostate-specific membrane antigen (PSMA) have been used in prostate cancer. Moreover, PSMA is also overexpressed on neovessels in hepatocellular carcinoma (HCC). This study aimed to preliminarily evaluate the diagnostic effectiveness of [<sup>68</sup>Ga]Ga-PSMA-617 PET/MRI for HCC.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients suspected of HCC were prospectively enrolled in this single-center study (NCT05006326, 2021-08-16) to perform [<sup>68</sup>Ga]Ga-PSMA-617 PET/MRI, along with contrast enhanced CT (ceCT) or ceMRI. The main suspicious intrahepatic lesions were resected and pathologically verified. Visual evaluation of [<sup>68</sup>Ga]Ga-PSMA-617 PET/MRI images was performed on all lesions. Maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), tumor-to-liver ratio (TLR), tumor-to-blood ratio (TBR), and tumor-to-parotid ratio (TPR) were measured or calculated. The diagnostic efficiency of different modalities was summarized. PSMA expression was evaluated by immunohistochemistry and the correlation of PSMA expression and [<sup>68</sup>Ga]Ga-PSMA-617 uptake in HCC primary tumors was quantitatively analyzed.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 12 patients (ten men and two women; mean age 58.75 ± 12.08 years) were included. Ten patients were diagnosed with HCC, 2 with intrahepatic cholangiocarcinoma (ICC), and 4 with hemangioma. The SUVmax, TLR, TBR, and TPR of HCC primary tumors were higher than those of ICC and hemangioma. The diagnostic accuracy of [<sup>68</sup>Ga]Ga-PSMA-617 PET/MRI for primary HCC was 82.4%. When combined with ceCT or ceMRI, the accuracy increased to 88.2%. A moderate correlation was observed between SUVmax and mean PSMA expression in HCC primary tumors (<i>R</i> = 0.788).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Utilizing a hybrid PET/MRI system to combine [<sup>68</sup>Ga]Ga-PSMA-617 PET/MRI with ceMRI is a promising one-stop solution for the accurate diagnosis of HCC.</p><h3 data-test=\"abstract-sub-heading\">Trial Registration</h3><p>NCT05006326. Registered August 16, 2021, https://clinicaltrials.gov/study/NCT05006326.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"254 1","pages":""},"PeriodicalIF":8.6000,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nuclear Medicine and Molecular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00259-024-06973-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

Radiolabeled probes targeting prostate-specific membrane antigen (PSMA) have been used in prostate cancer. Moreover, PSMA is also overexpressed on neovessels in hepatocellular carcinoma (HCC). This study aimed to preliminarily evaluate the diagnostic effectiveness of [⁶⁸Ga]Ga-PSMA-617 PET/MRI for HCC.

Methods

Patients suspected of HCC were prospectively enrolled in this single-center study (NCT05006326, 2021-08-16) to perform [⁶⁸Ga]Ga-PSMA-617 PET/MRI, along with contrast enhanced CT (ceCT) or ceMRI. The main suspicious intrahepatic lesions were resected and pathologically verified. Visual evaluation of [⁶⁸Ga]Ga-PSMA-617 PET/MRI images was performed on all lesions. Maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), tumor-to-liver ratio (TLR), tumor-to-blood ratio (TBR), and tumor-to-parotid ratio (TPR) were measured or calculated. The diagnostic efficiency of different modalities was summarized. PSMA expression was evaluated by immunohistochemistry and the correlation of PSMA expression and [⁶⁸Ga]Ga-PSMA-617 uptake in HCC primary tumors was quantitatively analyzed.

Results

A total of 12 patients (ten men and two women; mean age 58.75 ± 12.08 years) were included. Ten patients were diagnosed with HCC, 2 with intrahepatic cholangiocarcinoma (ICC), and 4 with hemangioma. The SUVmax, TLR, TBR, and TPR of HCC primary tumors were higher than those of ICC and hemangioma. The diagnostic accuracy of [⁶⁸Ga]Ga-PSMA-617 PET/MRI for primary HCC was 82.4%. When combined with ceCT or ceMRI, the accuracy increased to 88.2%. A moderate correlation was observed between SUVmax and mean PSMA expression in HCC primary tumors (R = 0.788).

Conclusion

Utilizing a hybrid PET/MRI system to combine [⁶⁸Ga]Ga-PSMA-617 PET/MRI with ceMRI is a promising one-stop solution for the accurate diagnosis of HCC.

Trial Registration

NCT05006326. Registered August 16, 2021, https://clinicaltrials.gov/study/NCT05006326.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

用于疑似肝细胞癌患者成像的[68Ga]Ga-PSMA-617 PET/MRI

目的针对前列腺特异性膜抗原（PSMA）的放射性标记探针已被用于前列腺癌的研究。此外，PSMA 也在肝细胞癌（HCC）的新生血管上过度表达。本研究旨在初步评估[68Ga]Ga-PSMA-617 PET/MRI对HCC的诊断效果。方法：本单中心研究（NCT05006326，2021-08-16）前瞻性地纳入了疑似HCC患者，对其进行[68Ga]Ga-PSMA-617 PET/MRI以及对比增强CT（ceCT）或ceMRI检查。肝内主要可疑病灶均已切除并进行了病理验证。对所有病灶的[68Ga]Ga-PSMA-617 PET/MRI图像进行目测评估。测量或计算最大标准摄取值（SUVmax）、平均标准摄取值（SUVmean）、肿瘤肝比（TLR）、肿瘤血比（TBR）和肿瘤腮腺比（TPR）。总结了不同模式的诊断效率。结果共纳入 12 例患者（10 男 2 女；平均年龄 58.75 ± 12.08 岁）。10名患者被诊断为HCC，2名患者被诊断为肝内胆管癌（ICC），4名患者被诊断为血管瘤。HCC原发肿瘤的SUVmax、TLR、TBR和TPR均高于ICC和血管瘤。68Ga]Ga-PSMA-617 PET/MRI 对原发性 HCC 的诊断准确率为 82.4%。当与ceCT或ceMRI结合使用时，准确率提高到88.2%。结论利用混合PET/MRI系统将[68Ga]Ga-PSMA-617 PET/MRI与ceMRI相结合，是准确诊断HCC的一种很有前景的一站式解决方案。注册时间：2021年8月16日，https://clinicaltrials.gov/study/NCT05006326。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

European Journal of Nuclear Medicine and Molecular Imaging 医学-核医学

CiteScore

15.60

自引率

9.90%

发文量

392

审稿时长

3 months

期刊介绍： The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.