Dietary Polyphenols as Potential Therapeutic Agents in Type 2 Diabetes Management: Advances and Opportunities

IF 8 1区医学 Q1 NUTRITION & DIETETICS Advances in Nutrition Pub Date : 2025-01-01 DOI:10.1016/j.advnut.2024.100346

Sisir Kumar Barik , Srabasti Sengupta , Rakesh Arya , Surendra Kumar , Jong Joo Kim , Reetika Chaurasia

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Abstract

Poor dietary intake or unhealthy lifestyle contributes to various health disorders, including postprandial hyperglycemia, leading to type 2 diabetes mellitus (T2DM). Reduction of postprandial glucose concentrations through diet is a key strategy for preventing and managing T2DM. Thus, it is essential to understand how dietary components affect glycemic regulation. Dietary polyphenols (DPs), such as anthocyanins and other phenolics found in various fruits and vegetables, are often recommended for their potential health benefits, although their systemic effectiveness is subject to ongoing debate. Therefore, this review assesses the current and historical evidence of DPs bioactivities, which regulate crucial metabolic markers to lower postprandial hyperglycemia. Significant bioactivities such as modulation of glucose transporters, activation of AMP kinase, and regulation of incretins are discussed, along with prospects for diet-induced therapeutics to prevent the onset of T2DM.

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膳食多酚作为治疗 2 型糖尿病的潜在药物：进展与机遇。

不良的饮食摄入或不健康的生活方式会导致各种健康问题，包括餐后高血糖，从而引发 2 型糖尿病（T2DM）。通过饮食降低餐后血糖水平是预防和控制 T2DM 的关键策略。因此，了解膳食成分如何影响血糖调节至关重要。膳食多酚（DPs），如各种水果和蔬菜中的花青素和其他酚类物质，因其潜在的健康益处而经常被推荐使用，但其系统有效性仍存在争议。因此，本综述评估了 DPs 生物活性的当前和历史证据，这些生物活性可调节关键的代谢指标，从而降低餐后高血糖。本文讨论了葡萄糖转运体的调节、5'单磷酸腺苷激活蛋白激酶（AMPK）的激活和增量蛋白的调节等重要的生物活性，以及饮食诱导疗法预防 T2DM 发病的前景。意义说明：这篇综述独特地综合了有关膳食多酚（DPs）代谢生物活性的当前和历史数据，尤其侧重于其机制，如葡萄糖转运体调节、AMPK 激活和增量蛋白调节，这可能有助于降低餐后高血糖，从而为膳食诱导的 T2DM 预防策略提供更全面的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Nutrition 医学-营养学

CiteScore

17.40

自引率

2.20%

发文量

117

审稿时长

56 days

期刊介绍： Advances in Nutrition (AN/Adv Nutr) publishes focused reviews on pivotal findings and recent research across all domains relevant to nutritional scientists and biomedical researchers. This encompasses nutrition-related research spanning biochemical, molecular, and genetic studies using experimental animal models, domestic animals, and human subjects. The journal also emphasizes clinical nutrition, epidemiology and public health, and nutrition education. Review articles concentrate on recent progress rather than broad historical developments. In addition to review articles, AN includes Perspectives, Letters to the Editor, and supplements. Supplement proposals require pre-approval by the editor before submission. The journal features reports and position papers from the American Society for Nutrition, summaries of major government and foundation reports, and Nutrient Information briefs providing crucial details about dietary requirements, food sources, deficiencies, and other essential nutrient information. All submissions with scientific content undergo peer review by the Editors or their designees prior to acceptance for publication.