Bone mineral density over ten years after primary parathyroidectomy in multiple endocrine neoplasia type 1.

IF 3.4 Q2 ENDOCRINOLOGY & METABOLISM JBMR Plus Pub Date : 2024-10-22 eCollection Date: 2024-12-01 DOI:10.1093/jbmrpl/ziae129

Emma Kuusela, Iiro Kostiainen, Elina Ritvonen, Eeva M Ryhänen, Camilla Schalin-Jäntti

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Abstract

Primary hyperparathyroidism (PHPT) associated with multiple endocrine neoplasia type 1 (MEN1) impairs bone mineral density and causes osteoporosis already in young patients. We aimed to investigate bone mineral density (BMD) in a contemporary cohort of patients with MEN1-related PHPT after long-term follow-up and compare these results with that of healthy controls. Thirty-five patients with genetically confirmed MEN1 were diagnosed with MEN1 at mean age 28.7 ± 13.6 years. Thirty-two (91.4%) underwent primary parathyroidectomy at mean age 33.3 ± 13.7 years; 12 had undergone at least 2 surgeries with on average 7.3 ± 5.9 years between the operations. BMD was assessed by DXA at the end of mean follow-up, 13.2 years after the primary parathyroidectomy and compared with that of 35 age- and gender-matched controls. More than 10 years after the first parathyroidectomy, mean BMD in patients with MEN1 is in the normal range. However, it is still significantly lower compared with healthy controls.

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多发性内分泌瘤 1 型甲状旁腺原发性切除术后十年的骨质密度。

与多发性内分泌肿瘤 1 型（MEN1）相关的原发性甲状旁腺功能亢进症（PHPT）会损害骨矿物质密度，并导致年轻患者出现骨质疏松症。我们的目的是调查一组与 MEN1 相关的 PHPT 患者长期随访后的骨矿物质密度（BMD），并将这些结果与健康对照组的结果进行比较。35 名经基因确诊的 MEN1 患者被确诊为 MEN1，平均年龄为 28.7 ± 13.6 岁。32人（91.4%）在平均年龄（33.3 ± 13.7）岁时接受了原发性甲状旁腺切除术；12人至少接受过两次手术，两次手术之间的平均间隔时间为（7.3 ± 5.9）年。在一次甲状旁腺切除术后 13.2 年的平均随访结束时，通过 DXA 对 BMD 进行了评估，并与 35 名年龄和性别匹配的对照组进行了比较。首次甲状旁腺切除术后 10 多年，MEN1 患者的平均 BMD 处于正常范围。不过，与健康对照组相比，其平均骨密度仍然明显偏低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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