Candidate gene polymorphisms associated with silicosis and coal workers' pneumoconiosis: a systematic review and meta-analysis.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM BMC Pulmonary Medicine Pub Date : 2024-11-22 DOI:10.1186/s12890-024-03392-0

Yingying Zhang, Di Sun, Yawen Song, Qiao Ye

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Abstract

Background: Silicosis and coal worker's pneumoconiosis primarily result from exposure to silica and coal dust. Despite similar exposure levels, individuals exhibit varying responses. This study aimed to address these gaps to explore the genetic factors influencing the development, severity, and associated complications.

Methods: A systematic literature search was performed across four databases-PubMed, Embase, Web of Science, and Cochrane Library-until July, 2023. Qualitative and quantitative analyses were applied to identify candidate genes.

Results: This study involved 83 articles and encompassed 545 individual studies, reviewing a total of 378 gene loci. After rigorous evaluation, we selected 8 candidate genes (TNFα-308, TNFα-238, GSTT1, IL-1α + 4845, IL-1β-511, IL-1β + 3953, IL-1RA + 2018, and IL-6-174) for meta-analysis. The analysis revealed that allele A of TNFα-308, allele A of TNFα-238, and allele C of IL-1RA + 2018 were identified as risk factors for the development of diseases.

Conclusions: This study established associations between specific genetic polymorphisms (TNFα-308, TNFα-238, and IL-1RA + 2018) and susceptibility to silicosis and coal worker's pneumoconiosis.

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与矽肺病和煤工尘肺病相关的候选基因多态性：系统回顾和荟萃分析。

背景：矽肺病和煤工尘肺病主要是由于接触二氧化硅和煤尘所致。尽管暴露水平相似，但个体的反应却各不相同。本研究旨在填补这些空白，探索影响发病、严重程度和相关并发症的遗传因素：在四个数据库（PubMed、Embase、Web of Science 和 Cochrane Library）中进行了系统的文献检索，直至 2023 年 7 月。应用定性和定量分析确定候选基因：本研究涉及 83 篇文章，包含 545 项单独研究，共审查了 378 个基因位点。经过严格评估，我们选择了 8 个候选基因（TNFα-308、TNFα-238、GSTT1、IL-1α + 4845、IL-1β-511、IL-1β + 3953、IL-1RA + 2018 和 IL-6-174）进行荟萃分析。分析结果显示，TNFα-308的等位基因A、TNFα-238的等位基因A和IL-1RA + 2018的等位基因C被确定为疾病发生的风险因素：本研究确定了特定基因多态性（TNFα-308、TNFα-238 和 IL-1RA + 2018）与矽肺病和煤工尘肺病易感性之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.