Anti-NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review.

IF 2.6 3区 医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Gynecology & Obstetrics Pub Date : 2024-11-23 DOI:10.1002/ijgo.16028
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang
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Abstract

Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra-limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti-NMDA (N-methyl-D-aspartate) receptor encephalitis was first described in 2007 and has become one of the most commonly recognized autoimmune encephalitides. The disease is predominantly female (81%) and affects young patients (37% <18 years old, 95% <45 years old), with up to 58% of women over 18 years old having ovarian teratoma. Clinical symptoms of anti-NMDA receptor encephalitis include psychiatric disorders (anxiety, agitation, bizarre behavior, hallucinations, delusions, and memory impairment); seizures and epileptic states; and other neurologic symptoms (muscle tone abnormalities, eye movement disorders, and central ventilatory disorders). Diagnosis of this condition can be difficult due to the non-specific nature of the symptoms, often leading to delays in appropriate treatment. Early diagnosis and timely treatment of anti-NMDA receptor encephalitis, especially in young women with ovarian teratoma, has significantly improved the chances of full recovery and improved reproductive health outcomes for patients.

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与卵巢畸胎瘤相关的抗NMDA受体自身免疫性脑炎:一个病例系列和文献综述。
自身免疫性脑炎是一组以边缘系统和边缘外系统功能障碍症状为特征的疾病,其发生与针对细胞内抗原、突触或神经细胞表面蛋白质的抗体有关。抗 NMDA(N-甲基-D-天冬氨酸)受体脑炎于 2007 年首次被描述,现已成为最常见的自身免疫性脑炎之一。该病以女性患者为主(81%),年轻患者占 37%。
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来源期刊
CiteScore
5.80
自引率
2.60%
发文量
493
审稿时长
3-6 weeks
期刊介绍: The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.
期刊最新文献
Complex cesarean section: Surgical approach to reduce the risks of intraoperative complications and postpartum hemorrhage. Does emotional freedom techniques affect premenstrual syndrome? A randomized controlled study. Exploring glycemic variability and time in range: Emerging indicators of at-risk pregnancy in type 2 diabetes mellitus. Informed consent and ethical issues pertaining to female sterilization-Scoping review. Comparative clinical and incremental cost-effectiveness analysis of treatments for pelvic inflammatory disease in southern Brazil.
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