{"title":"Oxalate nephropathy associated with glyoxylate-containing hair-straightening products: a call for caution","authors":"Naim M. Maalouf , Jonathan M. Whittamore","doi":"10.1016/j.kint.2024.09.015","DOIUrl":null,"url":null,"abstract":"<div><div>Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert <em>et al.</em> help elucidate the underlying mechanisms in a murine model that replicates the human pathology. Cutaneous absorption of glyoxylic acid from hair-straightening products and its subsequent conversion to oxalate are identified as crucial steps in the development of oxalate nephropathy. This newly described “skin-kidney” axis expands our understanding of oxalate metabolism, calls for additional studies to explore susceptibility to acute kidney injury following cutaneous glyoxylate exposure, and warrants vigilance around the use of these products.</div></div>","PeriodicalId":17801,"journal":{"name":"Kidney international","volume":"106 6","pages":"Pages 1023-1025"},"PeriodicalIF":14.8000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney international","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S008525382400718X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent reports have described acute kidney injury in otherwise healthy individuals after exposure to hair-straightening products. In this issue, Robert et al. help elucidate the underlying mechanisms in a murine model that replicates the human pathology. Cutaneous absorption of glyoxylic acid from hair-straightening products and its subsequent conversion to oxalate are identified as crucial steps in the development of oxalate nephropathy. This newly described “skin-kidney” axis expands our understanding of oxalate metabolism, calls for additional studies to explore susceptibility to acute kidney injury following cutaneous glyoxylate exposure, and warrants vigilance around the use of these products.
期刊介绍：
Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide.
KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics.
The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.
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