The predictive value of pan-immune inflammatory index for early recurrence of atrial fibrillation after cryoablation.

IF 2 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS BMC Cardiovascular Disorders Pub Date : 2024-11-23 DOI:10.1186/s12872-024-04329-5

Pengyang Gu, Peng Xu, Yiqun Chen, Jingyu Li, Hanrui Sun, Haixia Xu, Qi Lu

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Abstract

Objective: The pan-immune inflammatory (PIV) index holds prognostic value for cardiovascular diseases. This study aimed to investigate the predictive value of the PIV index regarding recurrence of atrial fibrillation (AF) after cryoballoon ablation (CBA).

Methods: The study included 307 patients with AF. Four inflammatory markers, namely, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation (SII) index, and PIV index, were used as indicators. COX regression analysis was conducted to evaluate the predictive value of AF recurrence after CBA. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated to evaluate the discriminative power of the indicators.

Result: The PIV index [94.9 (168.9,504.9) vs. 143.2 (98.2,210.6), P < 0.01] and SII index [366.3 (256.6,491.9) vs. 569.9 (658.1,438.4), P < 0.01] were significantly higher in the recurrence group. Univariable COX regression analysis showed that these four indices, persistent AF, and left atrial diameter (LAD) were all associated with AF recurrence. In multivariable regression analysis, the PIV index, persistent AF, and LAD (all P < 0.05) were independent predictors of postoperative AF recurrence. The ROC curve analysis showed that the PIV index had a higher predictive value for AF recurrence (AUC = 0.768, P < 0.01, 95% CI: 0.696-0.840) than the SII index and NLR. Kaplan-Meier analysis showed that patients with a PIV index > 260.7 had a higher recurrence rate at 1-year follow-up (P < 0.01). Subgroup analysis indicated that PIV had a predictive value in patients with different types of AF.

Conclusion: PIV index may be a potential biomarker for predicting relapse in patients with AF after CBA.

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泛免疫炎症指数对冷冻消融术后心房颤动早期复发的预测价值。

目的：泛免疫炎症指数（PIV）对心血管疾病具有预后价值：泛免疫炎症（PIV）指数对心血管疾病具有预后价值。本研究旨在探讨 PIV 指数对冷冻球囊消融术（CBA）后心房颤动（AF）复发的预测价值：研究纳入了 307 名房颤患者。方法：研究纳入了 307 名房颤患者，以四种炎症指标为指标，即中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症（SII）指数和 PIV 指数。采用 COX 回归分析评估 CBA 后房颤复发的预测价值。绘制接收者操作特征曲线（ROC），并计算曲线下面积（AUC），以评估指标的鉴别力：结果：PIV 指数[94.9（168.9,504.9） vs. 143.2（98.2,210.6），P 260.7]在随访 1 年时的复发率更高（P 结论：PIV 指数可能是一种潜在的生物检测指标：PIV 指数可能是预测 CBA 后房颤患者复发的潜在生物标志物。

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来源期刊

BMC Cardiovascular Disorders CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.50

自引率

0.00%

发文量

480

审稿时长

1 months

期刊介绍： BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.