The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review.

IF 3.6 4区医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-11-23 DOI:10.1007/s10571-024-01513-1

Zhixin Zhang, Zhiyu Zhang, Peng Liu, Xinmiao Xue, Chi Zhang, Lili Peng, Weidong Shen, Shiming Yang, Fangyuan Wang

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Abstract

Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular pathways by altering cell membrane potentials, leading to beneficial biological effects such as anti-inflammatory and neuroregenerative responses. This review compiles studies from PubMed up to March 2024, investigating the impact of light at wavelengths ranging from 620 to 1270 nm on ion channels. Out of 330 articles screened, 19 met the inclusion criteria. Research indicates that PBM can directly affect various ion channels by influencing neurotransmitter synthesis in neighboring cells, impacting receptors like glutamate and acetylcholine, as well as potassium, sodium channels, and transient receptor potential channels. The diversity of studies hampers a comprehensive meta-analysis for evaluating treatment strategies effectively. This systematic review aims to explore the potential role of optoelectronic signal transduction in PBM, studying the neurobiological mechanisms and therapeutic significance of PBM on ion channels. However, the lack of uniformity in current treatment methods underscores the necessity of establishing standardized and reliable therapeutic approaches.

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光生物调制在调节神经系统离子通道中的作用：系统综述。

光生物调节（PBM）是一种安全有效的神经疗法，它通过改变细胞膜电位来调节细胞通路，从而产生有益的生物效应，如抗炎和神经再生反应。本综述汇编了 PubMed 上截至 2024 年 3 月的研究，这些研究调查了波长为 620 到 1270 纳米的光对离子通道的影响。在筛选出的 330 篇文章中，有 19 篇符合纳入标准。研究表明，PBM 可通过影响邻近细胞的神经递质合成、影响谷氨酸和乙酰胆碱等受体以及钾、钠通道和瞬时受体电位通道，直接影响各种离子通道。研究的多样性阻碍了对治疗策略进行有效评估的全面荟萃分析。本系统综述旨在探讨光电信号转导在 PBM 中的潜在作用，研究 PBM 对离子通道的神经生物学机制和治疗意义。然而，目前的治疗方法缺乏统一性，这凸显了建立标准化、可靠的治疗方法的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.