Classification of colorectal cancer patients based on serum micronutrients: An exploratory investigation

IF 3.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Trace Elements in Medicine and Biology Pub Date : 2024-11-15 DOI:10.1016/j.jtemb.2024.127564
Krishnamurthy Hari , Rosanna Squitti , Jophi Bosco , Vasanth Jayaraman , Karthik Krishna , Amit Pal , Anastasia De Luca , Laura Di Veroli , Gioia Mastromoro , Gianluca Rizzo , Vincenzo Tondolo , Mauro Rongioletti
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Abstract

Background

Colorectal cancer (CRC) is a growing global health challenge with a multifactorial etiology encompassing genetic susceptibility, nutrition, and inflammation in the bowel.

Objective

To examine micronutrient status in CRC patients undergoing CRC resection.

Design

We performed a case-control study including 13 consecutive CRC patients and 10 healthy controls (CTRL) comparing the serum levels of 29 micronutrients, namely Copper, Zinc, Selenium, Chromium, Manganese, Carnitine, Choline, Inositol, Methylmalonic acid (MMA), Vitamin (Vit) B1, Vit B2, Vit B3, Vit B5, Vit B6, Vit C, Vit A, Vit D3, Vit E, Vit K1, Vit K2 and the amino acids Serine, Valine, Leucine, Isoleucine, Asparagine, Glutamine, Arginine, Citrulline and Cysteine.

Results

After considering the effect of age and sex, copper, arginine, and cysteine were increased, while zinc, selenium, chromium, Vit B1, Vit K1, and Vit A were decreased in CRC patients in comparison with CTRL. Zinc levels perfectly predicted the diagnosis of CRC, and were associated with lymph nodes (pN), of the pTNM staging. Copper levels in serum were strongly associated with the pathological pTNM staging of CRC.

Conclusion

Though this is a preliminary study that needs confirmation with a larger longitudinal cohort, our results show that serum micronutrients are linked to tumor growth, likely caused by increased demand from tumor tissue associated with an aberrant cell proliferation and changes in the antioxidant function.
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根据血清微量营养素对结直肠癌患者进行分类:一项探索性研究
背景:结直肠癌(CRC)是一个日益严重的全球性健康挑战,其病因是多因素的,包括遗传易感性、营养和肠道炎症:研究接受 CRC 切除术的 CRC 患者的微量营养素状况:设计:我们进行了一项病例对照研究,包括 13 名连续的 CRC 患者和 10 名健康对照(CTRL),比较了 29 种微量营养素的血清水平,即铜、锌、硒、铬、锰、肉碱、胆碱、肌醇、甲基丙二酸(MMA)、维生素 A、维生素 B、维生素 C 和维生素 D、甲基丙二酸(MMA)、维生素 B1、维生素 B2、维生素 B3、维生素 B5、维生素 B6、维生素 C、维生素 A、维生素 D3、维生素 E、维生素 K1、维生素 K2 和氨基酸丝氨酸、缬氨酸、亮氨酸、异亮氨酸、天冬酰胺、谷氨酰胺、精氨酸、瓜氨酸和半胱氨酸。结果考虑到年龄和性别的影响,与 CTRL 相比,CRC 患者的铜、精氨酸和半胱氨酸含量增加,而锌、硒、铬、维生素 B1、维生素 K1 和维生素 A 含量减少。锌水平可完美预测 CRC 的诊断,并与 pTNM 分期中的淋巴结(pN)相关。血清中的铜水平与 CRC 的病理 pTNM 分期密切相关:尽管这只是一项初步研究,还需要更大规模的纵向队列来证实,但我们的研究结果表明,血清中的微量营养素与肿瘤生长有关,这可能是由于肿瘤组织对微量营养素的需求增加、细胞异常增殖以及抗氧化功能发生变化所致。
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来源期刊
CiteScore
6.60
自引率
2.90%
发文量
202
审稿时长
85 days
期刊介绍: The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.
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