Spatial mapping of Alzheimer’s disease across genetic subtypes

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY Nature genetics Pub Date : 2024-11-25 DOI:10.1038/s41588-024-01895-4

Alexi Nott, Inge R. Holtman

引用次数: 0

Abstract

Alzheimer’s disease is a complex, heterogeneous disorder with multiple genetic subtypes. Spatial and single-cell gene expression analyses of these subtypes have provided new insights into general and subtype-specific cellular and molecular mechanisms of Alzheimer’s disease.

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跨基因亚型的阿尔茨海默病空间分布图

阿尔茨海默病是一种复杂的异质性疾病，有多种遗传亚型。对这些亚型进行的空间和单细胞基因表达分析为了解阿尔茨海默病的一般和亚型特异性细胞和分子机制提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution

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