{"title":"Selective and sensitive detection of glutathione with a novel fluorescein-based probe in fully aqueous media and its application in food samples","authors":"Garen Suna , Sema Topal , Erman Karakuş","doi":"10.1016/j.dyepig.2024.112551","DOIUrl":null,"url":null,"abstract":"<div><div>We devised a novel fluorescent probe, <strong>FL–T</strong>, bearing fluorescein and thienyl acrylic acid moiety, which was designed and synthesised to detect glutathione (GSH). Utilising micelle-catalysed cyclisation/elimination reaction, <strong>FL–T</strong> demonstrated exceptional sensitivity and operability in a fully aqueous solution, with a low limit of detection (LOD = 41.2 nM), and superior selectivity over cysteine (Cys), homocysteine (Hcy), H<sub>2</sub>S and other analytes. Furthermore, <strong>FL–T</strong> successfully detected GSH in fruit and vegetable samples. These findings suggest that <strong>FL–T</strong> is a promising tool for detecting GSH in various environments.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"234 ","pages":"Article 112551"},"PeriodicalIF":4.1000,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dyes and Pigments","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S014372082400617X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
We devised a novel fluorescent probe, FL–T, bearing fluorescein and thienyl acrylic acid moiety, which was designed and synthesised to detect glutathione (GSH). Utilising micelle-catalysed cyclisation/elimination reaction, FL–T demonstrated exceptional sensitivity and operability in a fully aqueous solution, with a low limit of detection (LOD = 41.2 nM), and superior selectivity over cysteine (Cys), homocysteine (Hcy), H2S and other analytes. Furthermore, FL–T successfully detected GSH in fruit and vegetable samples. These findings suggest that FL–T is a promising tool for detecting GSH in various environments.
期刊介绍：
Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied.
Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media.
The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.
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