Min Qi , Jie Liao , Bingbing Wang , Wei He , Shuyan Liu , Shuyu Liu , Yuntao Di , Qiang Cai , Zhiwei Xu , Xiaoming Li
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引用次数: 0
Abstract
The unique functions of the natural dura mater necessitate the design of dural restorations with a multilayered structure to achieve multifunctionality of anti-leakage, anti-adhesion, and pro-regenerative. Due to the barrier effect of the anti-leakage or anti-adhesion layer on cells, the pro-regenerative layer repairs dural defects mainly by inducing meningeal fibroblasts at the edge of defects. Hence, constructing scaffolds that provide fast and straight migration pathways and strong migration dynamics is the key to achieving fast defect repair. In this study, a radical-structured scaffold coated with concentration-gradient acellular small intestinal submucosa (SIS) is designed and constructed. The scaffold provides a straight channel with about 75 μm of width suitable for cell invasion and strong migration dynamics caused by SIS coating. Both in vitro and in vivo experiments demonstrate its superior efficacy in promoting cellular invasion and tissue regeneration compared to random-structured scaffold. Specifically, cell migration in the scaffolds at day 14 after implantation, and collagen deposition and angiogenesis at day 28 after implantation were elevated 4.43-, 0.51-, and 2.61-fold, respectively. These enhancement effects were further improved after being coated with SIS. Consequently, this radical-structured scaffold coated with concentration-gradient SIS is promising for promoting rapid dural regeneration.
期刊介绍：
Composites Part B: Engineering is a journal that publishes impactful research of high quality on composite materials. This research is supported by fundamental mechanics and materials science and engineering approaches. The targeted research can cover a wide range of length scales, ranging from nano to micro and meso, and even to the full product and structure level. The journal specifically focuses on engineering applications that involve high performance composites. These applications can range from low volume and high cost to high volume and low cost composite development.
The main goal of the journal is to provide a platform for the prompt publication of original and high quality research. The emphasis is on design, development, modeling, validation, and manufacturing of engineering details and concepts. The journal welcomes both basic research papers and proposals for review articles. Authors are encouraged to address challenges across various application areas. These areas include, but are not limited to, aerospace, automotive, and other surface transportation. The journal also covers energy-related applications, with a focus on renewable energy. Other application areas include infrastructure, off-shore and maritime projects, health care technology, and recreational products.
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