Xueqi Bai , Shihang Li , Jiayang Yang , Ying Lu , Rong Li , Jianbo Song , Xiudong Guo
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引用次数: 0
Abstract
Sonodynamic therapy (SDT) is a non-invasive anti-tumor strategy with good efficacy, strong penetration and few side effects. However, the microenvironment of tumor hypoxia and high expression of hydrogen peroxide (H2O2) limits the efficiency of SDT. In this work, we have prepared a ultrasound-enhanced anti-tumor material by hydrothermal method, and the nanomaterials with optimal catalytic ability are identified by controlling the quality of curcumin (Fe3O4/Cur). The Fe3O4/Cur is not only capable of generating ROS by ultrasound excitation, but also generates ROS by the Fenton reaction with H2O2, and the SDT effect of Fe3O4/Cur is further enhanced. Under ultrasound stimulation, the Fe3O4/Cur can effectively kill the breast cancer cells within 15 min. This work provides a new idea for the treatment of breast cancer.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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