N Bukia, L Machavariani, M Butskhrikidze, M Svanidze, M Siradze
{"title":"ELECTROMAGNETIC STIMULATION REGULATES BLOOD CORTICOSTERONE LEVELS IN IMMOBILIZED RATS: GENDER DIFFERENCES.","authors":"N Bukia, L Machavariani, M Butskhrikidze, M Svanidze, M Siradze","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A mental disorder is a condition that affects an individual's cognition, emotional regulation, or behavior, causing distress or impairing main areas of functioning. The effects of electromagnetic stimulation (EMS) and oxytocin (OXY) on blood corticosterone (CORT) levels in immobilized (10 days, 2 hours a day or one time, 2 hours) male and female rats while accounting for their sex hormone levels were studied. The experiments were conducted on intact and gonadectomized rats. As a result of immobilization, the content of CORT in the blood increased in both groups of rats. Chronic immobilization stress dysregulates HPA axis function in rats of both sexes. Repeated EMS and OXY intranasal (IN OXY) (18 IU) (after each session of immobilization) or intracerebroventricular (1 μl/animal) returned the blood CORT level to normal. The effects of EMS and IN OXY were significant in intact rats compared with gonadectomized rats. EMS and IN OXY enhance the negative feedback of CORT.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 354","pages":"36-41"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Georgian medical news","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
A mental disorder is a condition that affects an individual's cognition, emotional regulation, or behavior, causing distress or impairing main areas of functioning. The effects of electromagnetic stimulation (EMS) and oxytocin (OXY) on blood corticosterone (CORT) levels in immobilized (10 days, 2 hours a day or one time, 2 hours) male and female rats while accounting for their sex hormone levels were studied. The experiments were conducted on intact and gonadectomized rats. As a result of immobilization, the content of CORT in the blood increased in both groups of rats. Chronic immobilization stress dysregulates HPA axis function in rats of both sexes. Repeated EMS and OXY intranasal (IN OXY) (18 IU) (after each session of immobilization) or intracerebroventricular (1 μl/animal) returned the blood CORT level to normal. The effects of EMS and IN OXY were significant in intact rats compared with gonadectomized rats. EMS and IN OXY enhance the negative feedback of CORT.
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