Role of Chemokines and Cytokines in Prostate Cancer Skeletal Metastasis.

IF 4.3 2区医学 Current Osteoporosis Reports Pub Date : 2024-11-25 DOI:10.1007/s11914-024-00897-9

Yusuke Shiozawa, Keshab Raj Parajuli, Kenneth Pienta, Russell Taichman

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Abstract

Purpose of review: Once prostate cancer (PCa) bone metastases develop, the prognosis dramatically declines. The precise mechanisms regulating bone metastasis remain elusive. This review will explore recent findings related to cytokines and chemokines in the process of bone metastases.

Recent findings: We discuss the role of cytokines in tumor growth, invasion, bone remodelling and angiogenesis and immune regulation in PCa skeletal metastases. Major advances in our understanding focus on immune evasion, immune checkpoint blockade, tumor-associated macrophages (TAMs), CAR-T cells, cytokine regulation of matrix metalloproteinases, cytokines including IL-10, IL-27, Interferon-γ, prostate transmembrane protein androgen induced 1 (Pmepa1), and regulation of RUNX2 transcription in supporting survival and growth of disseminated tumor cells (DTCs) and metastases development. The review highlights the complexity of cytokine actions in PCa bone metastases, suggesting potential therapeutic targets to disrupt interactions between cancer cells and their microenvironment.

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趋化因子和细胞因子在前列腺癌骨骼转移中的作用

回顾的目的：前列腺癌（PCa）一旦发生骨转移，预后就会急剧下降。骨转移的确切调控机制仍然难以捉摸。本综述将探讨骨转移过程中与细胞因子和趋化因子有关的最新发现：我们讨论了细胞因子在肿瘤生长、侵袭、骨重塑和血管生成中的作用，以及 PCa 骨骼转移中的免疫调节。我们对免疫逃避、免疫检查点阻断、肿瘤相关巨噬细胞（TAMs）、CAR-T 细胞、细胞因子对基质金属蛋白酶的调控、细胞因子（包括 IL-10、IL-27、干扰素-γ、前列腺跨膜蛋白雄激素诱导 1（Pmepa1））以及 RUNX2 转录调控在支持播散肿瘤细胞（DTCs）生存和生长以及转移发展中的作用等方面的认识取得了重大进展。综述强调了细胞因子在 PCa 骨转移中作用的复杂性，并提出了破坏癌细胞与其微环境之间相互作用的潜在治疗靶点。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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