Association of Body Mass Index with Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Interleukin-6 Based on Blood Pressure.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2024-04-01 DOI:10.61186/rbmb.13.1.137

Tjam Diana Samara, Magdalena Wartono, Adrianus Kosasih, Alvina Alvina

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Abstract

Background: A high body mass index (BMI) is known to be associated with high blood pressure. Levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and interleukin-6 (IL-6) are also increased in hypertensive patients. The aim of this study was to determine the correlation of BMI with MMP-9, TIMP-1, and IL-6 based on blood pressure.

Methods: The study design was cross-sectional with subjects aged >= 36 years, male and female and divided into 3 groups: group with normal blood pressure (NBP), group with controlled hypertension (CHT), and group with uncontrolled hypertension (UcHT). Height, weight, and blood pressure were measured, as well as serum levels of MMP-9, TIMP-1 and IL-6 using the ELISA method. The correlation was considered significant at p-value of < 0.05.

Results: The BMI in group UcHT was higher than in the other groups. There was a positive correlation between BMI and MMP-9; BMI and TIMP-1; and BMI and IL-6 (r=0.480, p=0.007; r=0.620; p=0.000; r=374, p=0.042 respectively) in group UcHT.

Conclusions: An increase in BMI is accompanied by an increase in levels of MMP-9, TIMP-1, and IL-6 in group UcHT, signifying that it is necessary to control BMI to maintain stable levels of MMP-9, TIMP-1, and IL-6, thereby keeping blood pressure under control.

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基于血压的体重指数与基质金属蛋白酶-9、组织金属蛋白酶抑制剂-1 和白细胞介素-6 的关系。

背景：众所周知，高体重指数（BMI）与高血压有关。高血压患者的基质金属蛋白酶-9（MMP-9）、金属蛋白酶组织抑制剂-1（TIMP-1）和白细胞介素-6（IL-6）水平也会升高。本研究旨在根据血压确定体重指数与 MMP-9、TIMP-1 和 IL-6 的相关性：研究设计为横断面研究，受试者年龄大于等于 36 岁，男女不限，分为 3 组：血压正常组（NBP）、控制性高血压组（CHT）和未控制性高血压组（UcHT）。采用 ELISA 方法测量身高、体重、血压以及血清中 MMP-9、TIMP-1 和 IL-6 的水平。相关性以 P 值小于 0.05 为显著：UcHT组的体重指数高于其他组。在 UcHT 组中，BMI 与 MMP-9、BMI 与 TIMP-1、BMI 与 IL-6 呈正相关（分别为 r=0.480，p=0.007；r=0.620；p=0.000；r=374，p=0.042）：结论：在 UcHT 组中，BMI 的增加伴随着 MMP-9、TIMP-1 和 IL-6 水平的增加，这表明有必要控制 BMI 以保持 MMP-9、TIMP-1 和 IL-6 水平的稳定，从而控制血压。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.