Interaction between intratumoral microbiota and neutrophils influences tumor progression.

Abstract

In recent years, complex interactions between intratumoral bacteria and neutrophils have been identified as significant factors in tumor occurrence and development. This commentary synthesizes findings from the past five years to explore these interactions. It is observed that during tumor progression, intratumoral bacteria promote neutrophil infiltration and the formation of neutrophil extracellular traps (NETs), which in turn drive tumor development and metastasis. Conversely, infiltrating neutrophils are also capable of slowing tumor progression by limiting the number of intratumoral bacteria. This dual role underscores a potential avenue for improving cancer treatment outcomes.