Flow electrosynthesis of phosphinamides and phosphoramidates through P–N coupling†

IF 9.3 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Green Chemistry Pub Date : 2024-10-22 DOI:10.1039/d4gc04450a
Tribani Boruah , Ren Ishizeki , Alberto Roldan , Rebecca L. Melen , Thomas Wirth
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Abstract

A robust flow electrochemical methodology operating under mild reaction conditions for P–N and P–O oxidative coupling has been developed. Potentiostatic and galvanostatic electrolyses were used to investigate reactant redox behaviour, showcasing a broad substrate scope (47 examples, up to 85% yield) across various chemical contexts.

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通过 P-N 偶联实现膦酰胺和膦酰胺酸盐的流动电合成†。
针对 P-N 和 P-O 氧化偶联,我们开发了一种在温和反应条件下运行的稳健的流动电化学方法。使用恒电位和恒电流电解来研究反应物的氧化还原行为,在各种化学背景下展示了广泛的底物范围(47 个实例,收率高达 85%)。
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来源期刊
Green Chemistry
Green Chemistry 化学-化学综合
CiteScore
16.10
自引率
7.10%
发文量
677
审稿时长
1.4 months
期刊介绍: Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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