Trends in the Detection of Erythropoietin Receptor Agonists (ERAs) in Anti-Doping: An Analysis of Recent Adverse Analytical Findings (AAFs).

IF 2.6 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS Drug Testing and Analysis Pub Date : 2024-11-25 DOI:10.1002/dta.3828

Tristan Equey, Julian Broséus, Norbert Baume, Reid Aikin

引用次数: 0

Abstract

Anti-doping efforts aim to reduce the prevalence of doping through a combination of education, deterrence, and detection. Detection of doping practices, for example through testing and/or investigations, aims both to catch committed dopers and deter potential dopers. To date, little empirical evidence is available examining the ability of detection strategies to deter athletes from doping. Here, trends in adverse analytical findings (AAFs) for EPO or other EPO-Receptor Agonists (ERAs) were examined over an 8-year period in order to assess the impact of ERA testing and detection on athlete behavior. It was observed that the majority (62.8%) of ERA AAFs occur on samples collected on the day of a competition. Evidence is also presented that the largest fraction of ERA AAFs occurs on the first sample ever taken from an athlete (43.2%), and that the ERA AAF rates decline steadily as athletes continue to be tested. These findings provide evidence of a deterrent effect of testing on ERA use in sport.

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反兴奋剂检测促红细胞生成素受体激动剂（ERAs）的趋势：近期阳性分析结果（AAFs）分析》。

反兴奋剂工作旨在通过教育、威慑和检测相结合的方式，减少兴奋剂的使用。对使用兴奋剂行为的检测，例如通过检测和/或调查，既是为了抓住坚定的使用兴奋剂者，也是为了威慑潜在的使用兴奋剂者。迄今为止，关于检测策略能否阻止运动员使用兴奋剂的实证研究还很少。本文对 8 年间 EPO 或其他 EPO 受体激动剂（ERA）的不良分析结果（AAFs）趋势进行了研究，以评估 ERA 检测和发现对运动员行为的影响。研究发现，大多数（62.8%）ERA AAFs 发生在比赛当天采集的样本中。还有证据表明，ERA AAFs 的最大部分发生在从运动员身上采集的第一份样本上（43.2%），而且随着运动员不断接受检测，ERA AAFs 的发生率也在稳步下降。这些发现证明了检测对在体育运动中使用ERA具有威慑作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Testing and Analysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

5.90

自引率

24.10%

发文量

191

审稿时长

2.3 months

期刊介绍： As the incidence of drugs escalates in 21st century living, their detection and analysis have become increasingly important. Sport, the workplace, crime investigation, homeland security, the pharmaceutical industry and the environment are just some of the high profile arenas in which analytical testing has provided an important investigative tool for uncovering the presence of extraneous substances. In addition to the usual publishing fare of primary research articles, case reports and letters, Drug Testing and Analysis offers a unique combination of; ‘How to’ material such as ‘Tutorials’ and ‘Reviews’, Speculative pieces (‘Commentaries’ and ‘Perspectives'', providing a broader scientific and social context to the aspects of analytical testing), ‘Annual banned substance reviews’ (delivering a critical evaluation of the methods used in the characterization of established and newly outlawed compounds). Rather than focus on the application of a single technique, Drug Testing and Analysis employs a unique multidisciplinary approach to the field of controversial compound determination. Papers discussing chromatography, mass spectrometry, immunological approaches, 1D/2D gel electrophoresis, to name just a few select methods, are welcomed where their application is related to any of the six key topics listed below.