Clinical Utility and Safety of an Ultrasonic Head Stimulator in Dementia With Lewy Bodies.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2024-11-26 DOI:10.1097/WAD.0000000000000652
Yuta Manabe
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Abstract

Background: The potential of Ultra-Ma, an ultrasonic head stimulator, for the supplementary treatment of dementia with Lewy bodies (DLB) was evaluated in patients with various symptoms under poor control by drug therapy.

Methods: Patients with DLB treated with choline esterase inhibitor or L-DOPA, either alone or in combination, and who met inclusion criteria were enrolled. Four weeks of placebo stimulation was followed by 8 weeks of active ultrasonic stimulation and a 4-week follow-up. Primary endpoints were the effects of ultrasonic head stimulation on both cognitive dysfunction and behavioral and psychological symptoms of dementia (BPSD). Cognitive dysfunction was evaluated using the Japanese versions of the Mini-Mental State Examination and Montreal Cognitive Assessment, and BPSD was assessed using the Neuropsychiatric Inventory Brief Questionnaire Form. For cognitive fluctuations, the Cognitive Fluctuation Inventory served as an index. Improvements in parkinsonism, activities of daily living, and caregiver burden were examined as secondary endpoints.

Results: Twelve patients were enrolled. The primary endpoint was significantly improved during the active stimulation period, as were secondary endpoint ratings for parkinsonism and caregiver burden. No notable adverse events occurred.

Conclusions: The findings suggest that ultrasonic head stimulation has supplementary potential when combined with drug treatment in DLB.

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超声波头部刺激器在路易体痴呆症中的临床实用性和安全性
背景:在药物治疗控制不佳的各种症状患者中评估了超声波头部刺激器 Ultra-Ma 辅助治疗路易体痴呆症(DLB)的潜力:方法:研究人员招募了接受胆碱酯酶抑制剂或左旋多巴单独或联合治疗的路易体痴呆患者,这些患者均符合纳入标准。在进行为期四周的安慰剂刺激后,再进行为期八周的主动超声波刺激和为期四周的随访。主要终点是头部超声波刺激对认知功能障碍以及痴呆症的行为和心理症状(BPSD)的影响。认知功能障碍采用日语版的迷你精神状态检查和蒙特利尔认知评估进行评估,BPSD则采用神经精神量表简明问卷表进行评估。认知波动量表作为认知波动的指标。帕金森病、日常生活活动和护理负担的改善情况作为次要终点进行研究:结果:共招募了 12 名患者。主要终点在主动刺激期间有明显改善,次要终点帕金森症和护理负担的评分也有明显改善。无明显不良事件发生:结论:研究结果表明,超声波头部刺激与药物治疗相结合,对 DLB 有辅助治疗的潜力。
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来源期刊
CiteScore
3.10
自引率
4.80%
发文量
88
期刊介绍: ​Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.
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