Rapid Determination of Toxic Trace Metals As, Hg, Tl, and Pb in Hair by Monochromatic Excitation X-ray Fluorescence Spectrometry.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biological Trace Element Research Pub Date : 2024-11-26 DOI:10.1007/s12011-024-04455-3

Shihao Wu, Peng Zhao, Aihua Wang, Linpei Dong, Xiaojun Wu, Jifen Wang, Yunfeng Zhang

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Abstract

Monochromatic excitation X-ray fluorescence (ME-XRF) spectrometry emerges as a novel technique in trace element analysis, distinguished by its simplicity, rapidity, and efficiency. Its application in forensic toxicology has grown significantly for identifying toxic trace metals in biological samples. This study further expands its utility by developing a method for the rapid determination of arsenic (As), mercury (Hg), thallium (Tl), and lead (Pb) in hair samples. Calibration curves were established using analytical reference samples, and optimal detection conditions were determined and validated. The LODs for As, Hg, Tl, and Pb were 0.03, 0.03, 0.03, and 0.05 μg g^-1, respectively. Method precision was evaluated through seven parallel analyses of samples within the concentration range of 0.27 to 20.051 μg g⁻¹, with relative standard deviations (RSDs) consistently below 10%. The feasibility of the ME-XRF technique for forensic toxicology analysis was validated through the analysis of authentic poisoned hair samples collected from the animal experiment.

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利用单色激发 X 射线荧光光谱法快速测定头发中的有毒痕量金属砷、汞、碲和铅。

单色激发 X 射线荧光光谱法（ME-XRF）是痕量元素分析领域的一项新技术，具有简便、快速和高效的特点。它在法医毒理学中的应用已显著增加，可用于鉴定生物样本中的有毒痕量金属。本研究开发了一种快速测定头发样本中砷（As）、汞（Hg）、铊（Tl）和铅（Pb）的方法，进一步扩大了其应用范围。利用分析参考样品建立了校准曲线，确定并验证了最佳检测条件。砷、汞、铊和铅的检测限分别为 0.03、0.03、0.03 和 0.05 μg g-1。通过对 0.27 至 20.051 μg g-1 浓度范围内的样品进行七次平行分析，评估了方法的精确度，相对标准偏差 (RSD) 始终低于 10%。通过分析从动物实验中采集的真实中毒毛发样本，验证了 ME-XRF 技术在法医毒理学分析中的可行性。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.