Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM BMC Endocrine Disorders Pub Date : 2024-11-25 DOI:10.1186/s12902-024-01789-w

Haolin Zhang, Weiyu Qiu, Ping Zhou, Li Shi, Ziting Chen, Yang Yang, Yonghao Lu, Lifei Zhou, Hua Zhang, Ming Cheng, Yang Ye, Rong Li

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Abstract

Objective: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity is often present concurrently. Nevertheless, the correlation between obesity, sex hormone levels, and blood lipid profiles in PCOS patients with IR remains uncertain.

Methods: This is a cross-sectional study including a total of 206 Chinese women diagnosed with PCOS, enrolled between March 2016 and December 2021. The participants' anthropometric measurements, such as weight, height, waist circumference, and hip circumference, were recorded. Additionally, fasting blood samples were collected to measure various parameters, including fasting glucose, insulin levels, lipid profiles, and sex hormone levels.

Results: Our findings highlight that obesity exhibited a significant correlation with lower levels of sex hormone binding globulin (SHBG) and elevated levels of free androgen index (FAI), fasting insulin, and HOMA-IR in PCOS patients diagnosed with IR. However, no significant association between obesity and blood lipid profiles was observed within this particular group of women.

Conclusion: This study suggests that among PCOS patients with IR, lower levels of SHBG and higher levels of FAI are associated with obesity. These findings indicate that SHBG and FAI may have the potential to serve as a biomarker for the initial identification and prognosis of IR in PCOS patients.

Trial registration: Retrospectively registered on 25/04/2020 at ClinicalTrials.gov Identifer: NCT04264832.

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肥胖与多囊卵巢综合症患者的 SHBG 水平有关，而不是与胰岛素抵抗的血脂状况有关。

目的：多囊卵巢综合征（PCOS）是一种常见的内分泌疾病，其特点是内分泌失调和胰岛素抵抗（IR）。在与多囊卵巢综合征相关的代谢异常中，肥胖往往同时存在。然而，多囊卵巢综合症患者的肥胖、性激素水平和血脂谱之间的相关性仍不确定：这是一项横断面研究，共纳入 206 名确诊为多囊卵巢综合征的中国女性，入组时间为 2016 年 3 月至 2021 年 12 月。研究记录了参与者的人体测量数据，如体重、身高、腰围和臀围。此外，还采集了空腹血样以测量各种参数，包括空腹血糖、胰岛素水平、血脂概况和性激素水平：我们的研究结果表明，肥胖与性激素结合球蛋白（SHBG）水平降低以及游离雄激素指数（FAI）、空腹胰岛素和 HOMA-IR 水平升高有显著相关性。然而，在这一特殊女性群体中，并未观察到肥胖与血脂谱之间存在明显关联：本研究表明，在患有 IR 的 PCOS 患者中，较低水平的 SHBG 和较高水平的 FAI 与肥胖有关。这些研究结果表明，SHBG 和 FAI 有可能成为 PCOS 患者 IR 的初步识别和预后的生物标志物：回顾性注册：2020年4月25日在ClinicalTrials.gov Identifer：NCT04264832注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.