Impact of Maternal Hepatitis B Virus Infection on Congenital Heart Disease Risk in Offspring: A National Cohort Study.

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Viral Hepatitis Pub Date : 2024-11-26 DOI:10.1111/jvh.14036
Yewan Park, Jihye Heo, Danbee Kang, Geum-Youn Gwak
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Abstract

Maternal hepatitis B virus (HBV) infection influence both maternal and fetal health. Recent studies reported increased congenital anomalies in offspring of HBV-infected mothers. This study investigated whether maternal HBV infection was associated with higher risk of congenital heart disease (CHD) in children. With the Korean National Health Insurance Service (K-NHIS) database, this retrospective cohort study included live births from 2005 to 2019, born to women under 40. Propensity score matching with a 1:3 ratio was conducted to compare HBV-infected mother's children with HBV-uninfected mother's children while adjusting for various maternal and pregnancy-related factors. Logistic regression models were used to estimate the risk. Of 2,673,059 eligible participants, 263,904 children were born to HBV-infected mothers. Risk estimation in this group showed a modestly increased risk of CHD (OR = 1.05, 95% CI = 1.02, 1.09). Notably, when pregnant mothers were treated with antiviral medication, there was an indication of reduced CHD risk, although this result was not statistically significant. The highest risk of CHD was observed in children who were themselves infected with HBV. The study indicates an association between maternal HBV infection and an increased CHD risk in offspring. The findings suggest the need to re-evaluate the timing of antiviral treatment during pregnancy to align more closely with early stages of fetal cardiac development. Further research is needed to understand the biological mechanisms of this association and to redefine clinical guidelines for managing HBV infection in pregnancy.

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母亲乙型肝炎病毒感染对后代先天性心脏病风险的影响:一项全国队列研究
母体感染乙型肝炎病毒(HBV)会影响母体和胎儿的健康。最近的研究报告称,HBV 感染母亲的后代先天性畸形增加。本研究调查了母体感染 HBV 是否与儿童先天性心脏病(CHD)的高风险相关。这项回顾性队列研究利用韩国国民健康保险服务(K-NHIS)数据库,纳入了2005年至2019年期间由40岁以下女性所生的活产婴儿。在调整各种母体和妊娠相关因素的同时,对感染 HBV 的母亲和未感染 HBV 的母亲的子女进行了倾向得分匹配,比例为 1:3。采用逻辑回归模型估算风险。在 2,673,059 名符合条件的参与者中,263,904 名儿童的母亲为 HBV 感染者。对这一群体的风险估算显示,罹患冠心病的风险略有增加(OR = 1.05,95% CI = 1.02,1.09)。值得注意的是,当孕妇接受抗病毒药物治疗时,有迹象表明其患冠心病的风险有所降低,尽管这一结果在统计学上并不显著。据观察,本身感染了 HBV 的儿童患心脏病的风险最高。这项研究表明,母体感染 HBV 与后代患先天性心脏病的风险增加之间存在关联。研究结果表明,有必要重新评估孕期抗病毒治疗的时机,使其与胎儿心脏发育的早期阶段更加一致。还需要进一步的研究来了解这种关联的生物学机制,并重新制定管理妊娠期 HBV 感染的临床指南。
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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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