Brief description of Mendelian randomized studies.

IF 2.7 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Revista Espanola De Enfermedades Digestivas Pub Date : 2024-11-26 DOI:10.17235/reed.2024.10917/2024
Joaquín González Aroca
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引用次数: 0

Abstract

Mendelian randomization (MR) offers a more rigorous framework than traditional observational studies by using genetic variants to assess causal relationships. Three critical assumptions are necessary for MR validity: relevance, independence, and exclusion restriction. These assumptions ensure that the genetic variants accurately reflect the risk factor's impact on the outcome. By elucidating these key points, this article aims to enhance understanding of MR's strengths and limitations in epidemiological research.

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孟德尔随机研究简介。
与传统的观察性研究相比,孟德尔随机法(MR)利用基因变异来评估因果关系,提供了一个更严格的框架。孟德尔随机法的有效性需要三个关键假设:相关性、独立性和排除限制。这些假设可确保基因变异准确反映风险因素对结果的影响。通过阐明这些关键点,本文旨在加深人们对 MR 在流行病学研究中的优势和局限性的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.00
自引率
25.00%
发文量
400
审稿时长
6-12 weeks
期刊介绍: La Revista Española de Enfermedades Digestivas, Órgano Oficial de la Sociedad Española de Patología Digestiva (SEPD), Sociedad Española de Endoscopia Digestiva (SEED) y Asociación Española de Ecografía Digestiva (AEED), publica artículos originales, editoriales, revisiones, casos clínicos, cartas al director, imágenes en patología digestiva, y otros artículos especiales sobre todos los aspectos relativos a las enfermedades digestivas.
期刊最新文献
A rare early gastric mixed neuroendocrine-non-neuroendocrine neoplasms misdignosed to early gastric cancer. Acute acalculous cholecystitis secondary to hepatitis A infection. Brief description of Mendelian randomized studies. Eosinophilic gastroenteritis: a rare cause of ileitis. Intestinal graft-versus-host disease.
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