{"title":"Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review","authors":"Elena Alina Chiticaru , Mariana Ioniță","doi":"10.1016/j.mtbio.2024.101341","DOIUrl":null,"url":null,"abstract":"<div><div>Bioprinting and bioinks are two of the game changers in bone tissue engineering. This review presents different bioprinting technologies including extrusion-based, inkjet-based, laser-assisted, light-based, and hybrid technologies with their own strengths and weaknesses. This review will aid researchers in the selection and assessment of the bioink; the discussion ranges from commercially available bioinks to custom lab-made formulations mainly based on natural polymers, such as agarose, alginate, gelatin, collagen, and chitosan, designed for bone tissue engineering. The review is centered on technological advancements and increasing clinical demand within the rapidly growing bioprinting market. From this point of view, 4D, 5D, and 6D printing technologies promise a future where unprecedented levels of innovation will be involved in fabrication processes leading to more dynamic multifunctionalities of bioprinted constructs. Further advances in bioprinting technology, such as hybrid bioprinting methods are covered, with the promise to meet personalized medicine goals while advancing patient outcomes for bone tissues engineering applications.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"29 ","pages":"Article 101341"},"PeriodicalIF":8.7000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590006424004022","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bioprinting and bioinks are two of the game changers in bone tissue engineering. This review presents different bioprinting technologies including extrusion-based, inkjet-based, laser-assisted, light-based, and hybrid technologies with their own strengths and weaknesses. This review will aid researchers in the selection and assessment of the bioink; the discussion ranges from commercially available bioinks to custom lab-made formulations mainly based on natural polymers, such as agarose, alginate, gelatin, collagen, and chitosan, designed for bone tissue engineering. The review is centered on technological advancements and increasing clinical demand within the rapidly growing bioprinting market. From this point of view, 4D, 5D, and 6D printing technologies promise a future where unprecedented levels of innovation will be involved in fabrication processes leading to more dynamic multifunctionalities of bioprinted constructs. Further advances in bioprinting technology, such as hybrid bioprinting methods are covered, with the promise to meet personalized medicine goals while advancing patient outcomes for bone tissues engineering applications.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).