Connecting single-molecule and super-resolution microscopies to cell biology through theoretical modeling.

IF 3.2 3区生物学 Q2 BIOPHYSICS Biophysical journal Pub Date : 2024-11-25 DOI:10.1016/j.bpj.2024.11.3308

Jian Liu, Taekjip Ha

引用次数: 0

Abstract

Recent developments of single-molecule and super-resolution microscopies reveal novel spatial-temporal features of various cellular processes with unprecedented details, and greatly facilitate the development of theoretical models. In this review, we synthesize our view of how to meaningfully integrate these experimental approaches with theoretical modeling to obtain deeper understanding of the physical mechanisms of cell biology.

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通过理论建模将单分子和超分辨率显微镜与细胞生物学联系起来。

单分子显微镜和超分辨率显微镜的最新发展以前所未有的细节揭示了各种细胞过程的新时空特征，极大地促进了理论模型的发展。在这篇综述中，我们将总结如何将这些实验方法与理论建模有意义地结合起来，以获得对细胞生物学物理机制的更深入理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysical journal 生物-生物物理

CiteScore

6.10

自引率

5.90%

发文量

3090

审稿时长

2 months

期刊介绍： BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.